| 雷公藤多苷片的抗炎作用及体内药效动力学研究 |
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| 引用本文： | 张秋萍,田振,刘志宏,宋洪涛.雷公藤多苷片的抗炎作用及体内药效动力学研究[J].中国实验方剂学杂志,2012,18(6):122-124. |
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| 作者姓名： | 张秋萍 田振 刘志宏 宋洪涛 |
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| 作者单位： | 1. 南京军区福州总医院药学科,福州,350025
2. 南京军区福州总医院药学科,福州 350025;福建中医药大学药学院,福州 350108 |
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| 基金项目： | 福建省卫生厅中医药科研课题(wzzd0906) |
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| 摘 要： | 目的:采用药理效应法探讨雷公藤多苷片的药效动力学参数.方法:将8组雄性Wistar大鼠,皮内注射0.1 mL完全弗氏佐剂(CFA)第14天后,制得佐剂性关节炎模型.然后,分别以白细胞介素-1(IL-1)和肿瘤坏死因子-α(TNF-α)含量变化率为效应指标测定雷公藤多苷片的药效动力学参数.结果:雷公藤多苷片大鼠ig给药后,以IL-1和TNF-α变化率为指标,时间体存量均符合二室开放模型,主要药代动力学参数分别为t1/2α0.230和0.196 h,t1/2β0.283和0.246 h,V1/F 2.174,1.798 L·kg -1,AUC0-∞1.236,1.578 mg· L-1·h-1.结论:雷公藤多苷片在大鼠体内药动学行为符合线性二室模型,在体内的分布和消除均较快.
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| 关 键 词： | 雷公藤多苷片 抗炎 佐剂性关节炎 药效动力学 |
| 收稿时间： | 2011/9/19 0:00:00 |
Anti-inflammation and Pharmacodynamics of Leigongteng Duogan Tablet |
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| ZHANG Qiu-ping,TIAN Zhen,LIU Zhi-hong and SONG Hong-tao.Anti-inflammation and Pharmacodynamics of Leigongteng Duogan Tablet[J].China Journal of Experimental Traditional Medical Formulae,2012,18(6):122-124. |
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| Authors: | ZHANG Qiu-ping TIAN Zhen LIU Zhi-hong and SONG Hong-tao |
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| Institution: | Deparment of Pharmacy, Fuzhou General Hospitol of Nanjing Military Area Command, Fuzhou 350025, China;Deparment of Pharmacy, Fuzhou General Hospitol of Nanjing Military Area Command, Fuzhou 350025, China; School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China;Deparment of Pharmacy, Fuzhou General Hospitol of Nanjing Military Area Command, Fuzhou 350025, China;Deparment of Pharmacy, Fuzhou General Hospitol of Nanjing Military Area Command, Fuzhou 350025, China |
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| Abstract: | Objective:To study the anti-inflammation and pharmacodynamics of Leigongteng Duogan Pian.Method:The model of adjuvant arthritis in mice was established with complete freund’s adjuvant(CFA) and the changes of interleukin-1(IL-1) and tumor necrosis factor-α(TNF-α) were determined to estimate the pharmacodynamics.Result:The results showed that concentration-time curves after iv leigongteng duogan tablet were fit to a two-compartment model,The t1/2α was 0.230,0.196 h,t1/2βwas 0.283,0.246 h,V1/F was 2.174,1.798 L·kg-1,AUC0-∞was 1.236,1.578 mg·L-1·h-1.Conclusion:Pharmacodynamics of anti-inflammation conforms to linear two-compartment model and the distribution and elimination are both fast in mouses in vivo. |
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| Keywords: | Leigongteng Duogan Pian anti-inflammation adjuvant arthritis pharmacodynamics |
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