五倍子提取物喷雾膜剂体外释放评价

目的:建立五倍子提取物喷雾膜剂的体外释放度测定方法,并考察其体外释药特性.方法:以没食子酸为考察指标,采用改良Franz扩散池装置,以半透膜为体外渗透屏障,HPLC测定接收液中没食子酸的含量,计算体外释放度.结果:促渗剂对五倍子提取物喷雾膜剂的释药效果影响不明显,方程拟合以一级动力学方程拟合效果最好.结论:五倍子提取物喷雾膜剂体外释放良好,具有一级动力学特征,不使用促渗剂即可达到较好的释放效果.

In vitro Release Evaluation for Spray Film of Extract from Galla Chinensis

Objective: To establish a determination method of in vitro release for spray film of extract from Galla Chinensis, and investigate its in vitro release characteristics. Method: With gallic acid as index,modified Franz diffusion cell was chosen with semi-permeable membrane as in vitro permeability barrier, the content of gallic acid was determined by HPLC and in vitro release of gallic acid was calculated. Result: Affect of penetration enhancers on release effect of this spray film was not obvious,equation of in vitro release model fitted best with Kinetic equation. Conclusion: This spray film had characteristics of good release and Kinetic equation, it could be achieved a better release effect without penetration enhancers.