| 高效液相色谱法测定桂利嗪胶囊的含量 |
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| 引用本文： | 许世辉,王芳,刘斌. 高效液相色谱法测定桂利嗪胶囊的含量[J]. 安徽医药, 2011, 15(11): 1362-1363 |
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| 作者姓名： | 许世辉 王芳 刘斌 |
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| 作者单位： | 许世辉 (安徽省阜阳市食品药品检验所,安徽,阜阳,236015) ； 王芳 (安徽省颍上县人民医院,安徽,颍上,236200) ； 刘斌 (安徽省食品药品监督管理局,安徽,合肥,230051) ； |
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| 摘 要： | 目的建立HPLC测定桂利嗪胶囊含量的方法。方法采用Kromasil C18(4.6 mm×250 mm,5μl)色谱柱,流动相为甲醇-0.2%三乙醇胺-三乙胺(85∶15∶0.03),检测波长254 nm;柱温30℃;流速1 ml.min-1;样品处理方法:精密称取装量差异下的内容物(相当于桂利嗪25 mg),置25 ml量瓶中,加甲醇至刻度,滤过,再精密量取续滤液5 ml置50 ml量瓶中,摇匀,用0.45μm微孔滤膜滤过,取续滤液,即得。结果桂利嗪在19.79～197.94 mg.L-1的浓度范围内与峰面积呈良好的线性关系,r=0.999 9,平均回收率99.5%,RSD为0.6%(n=9)。结论该方法准确、重现性好,可作为该制剂的含量测定方法。
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| 关 键 词： | 桂利嗪胶囊 HPLC 含量测定。 |
Determination of cinnarizine capsules by HPLC |
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| XU Shi-hui,WANG Fang,LIU Bin. Determination of cinnarizine capsules by HPLC[J]. Anhui Medical and Pharmaceutical Journal, 2011, 15(11): 1362-1363 |
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| Authors: | XU Shi-hui WANG Fang LIU Bin |
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| Affiliation: | 1.Fuyang Institute for Food and Drug Control,Fuyang 236015;2.Yingshang People＇s Hospital,Yingshang 236200; 3.Anhui Food and Drug Administration,Heifei 230051) |
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| Abstract: | Aim To eatablish a method for determining the content of Cinnarizine Capsules.Method The HPLC analysis was performed on Kromasil C18 column（4.6 mm×250 mm,5 μl） with mobile phase of CH3OH-0.2triethanolamine-triethylamine（v：v：v=85 ： 15 ：0.03）,the flow rate was1.0 mL·min-1,the detection wavelength was at 254nm and the column temperature was 30℃.Results The linear range of Cinnarizine was 19.79~197.94 mg·L-1,and the average recovery was 99.5% with RSD being 0.6（n=9）% Conclusion This method is accurate,reliable and appropriate to control the quality of Cinnarizine Capsules. |
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| Keywords: | Cinnarizine capsules HPLC content determination |
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