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Eosinophils in allergic reactions |
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| Authors: | Pierre Desreumaux Monique Capron |
| Affiliation: | aClinique des Maladies de l'Appareil Digestif et de la Nutrition, Hôpital Huriez, University Hospital, 59037 Lille Cedex, France;bINSERM U167, Institut Pasteur, 1 rue du Professeur Calmette, BP245, 59019 Lille Cedex, France |
| Abstract: | Mainly located in the skin or mucosa of patients with allergic diseases, eosinophils contribute directly to tissue damage and chronic inflammation. The past year has seen significant advances in the study of the factors involved in the specific tissue recruitment of eosinophils, including chemoattractants and their receptors. New data have been obtained on the synthesis by eosinophils of various cytokines mostly released by immune complexes. |
| Keywords: | Abbreviations: CKR chemokine receptor ECP eosinophil cationic protein EPO eosinophil peroxidase GM-CSF granulocyte macrophage-colony stimulating factor IFN interferon IL interleukin MCP monocyte chemotactic protein MIP macrophage inflammatory protein RANTES regulated on activation, normal T cell expressed and secreted s secretory SC secretory component TGF transforming growth factor VCAM vascular cell adhesion molecule VLA very late activation antigen |
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