| 紫杉醇联合顺铂、5-氟尿嘧啶治疗晚期食管癌近期疗效观察 |
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| 引用本文： | 刘玮玮,王建冰,陈文胜.紫杉醇联合顺铂、5-氟尿嘧啶治疗晚期食管癌近期疗效观察[J].安徽医药,2011,15(9):1154-1156. |
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| 作者姓名： | 刘玮玮 王建冰 陈文胜 |
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| 作者单位： | 安徽省合肥市第三人民医院肿瘤科,安徽,合肥,230022;安徽省合肥市第三人民医院肿瘤科,安徽,合肥,230022;安徽省合肥市第三人民医院肿瘤科,安徽,合肥,230022 |
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| 摘 要： | 目的 观察紫杉醇联合顺铂(DDP)加亚叶酸钙(CF)和5-氟尿嘧啶(5-FU)方案治疗晚期食管癌的近期疗效及安全性.方法 观察55例晚期食管癌患者,PTX 135～175 mg·m-2,静脉滴注3 h,d1,DDP 20 mg·m-2 d1～d4、CF 0.2g·m-2 d2～d3、5-FU 2.0g·m-2持续静滴4...
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| 关 键 词： | 晚期食管癌 紫杉醇 顺铂 亚叶酸钙 氟尿嘧啶 化疗 |
Clinical observation of paclitaxel cisplatin combined with fluorouracil therapy with advanced esophageal cancer |
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| LIU Wei-wei,WANG Jian-bing,CHEN Wen-sheng.Clinical observation of paclitaxel cisplatin combined with fluorouracil therapy with advanced esophageal cancer[J].Anhui Medical and Pharmaceutical Journal,2011,15(9):1154-1156. |
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| Authors: | LIU Wei-wei WANG Jian-bing CHEN Wen-sheng |
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| Institution: | (Department of Oncology,The Third People＇s Hospital,Hefei,Anhui 230022) |
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| Abstract: | Aim To evaluate the efficacy and toxicity of paclitaxel and cisplatin plus CF/fluorouracil regimen treatment in the advanced esophageal cancer.Methods 55 patients of advanced esophageal cancer were treated.The treatment schedule consisted of paclitaxel iv 135~175 mg·m-2,d1,and cisplatin 20 mg·m-2,iv,d1~d4 plus CF 0.2 g·m-2,iv,d2~d3,and fluorouracil 2 g·m-2,civ for 46 h,d2~d3 were administered every three weeks.Results All 55 patients were eligible for clinical response evaluation.The overall response rate was 56.3%,including 2 cases of CR,29 cases of PR,15 cases of SD and 9 cases of PD respectively.The major side-effects were neutropenia,gastrointestinal reaction,oral mucositis,peripheral neurotoxicity.Conclusion Paclitaxel and cisplatin plus CF / fluorouracil regimen has a palliative role in patients with a dvanced esophageal cancer. |
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| Keywords: | advanced esophaged cancer paclitaxel DDP CF fluorouracil chemotherapy |
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