Proposal of a score combining red blood cell indices for early differentiation of beta-thalassemia minor from iron deficiency anemia |
| |
Authors: | Janel Alexandre Roszyk Laurence Rapatel Chantal Mareynat Gabrielle Berger Marc G Serre-Sapin Anne-Françoise |
| |
Affiliation: | Hématologie Biologique/Immunologie, CHU, H?tel Dieu, Boulevard Léon Malfreyt, Clermont Ferrand, France. ajanel@chu-clermontferrand.fr |
| |
Abstract: | This study evaluates the diagnostic reliability of 11 red blood cells indices, together with our new index, referred to as '11T', in differentiation of beta-thalassemia minor (BTm) from iron deficiency anemia (IDA). A total of 129 patients with microcytic anemia were involved in a retrospective study, 80 with IDA and 49 with BTm. Using an automatic program, we calculated 11 discrimination indices and a new score, 11T, based on the results of these 11 tests. To confirm the interest of 11T, we performed a prospective study with 53 patients. 11T was most effective in differentiating BTm from IDA: 11T had the highest Youden's index (83%) and the best percentage of correctly identified patients (93%) and gave optimal performance in our prospective study. We proposed a score, 11T, which is able to discriminate between IDA and BTm with high specificity and high sensitivity in order to conduct the appropriate confirmatory examination. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|