黏蛋白MUC-1 MUC-2和MUC-3在大肠癌中的表达与临床意义

目的：探讨MUC1、MUC2及MUC3在大肠癌组织中的表达与临床病理指标之间的关系。方法：采用免疫组织化学法检测60例结直肠癌及癌旁相对正常黏膜组织中MUC1、MUC2、MUC3的表达。结果：MUC1、MUC2、MUC3在癌旁相对正常黏膜组织中的阳性表达率分别为11.7%、100%、100%,MUC1、MUC2、MUC3在结直肠癌组织中的阳性表达率分别为46.7%、60.0%、53.3%。黏蛋白MUC1的表达与结直肠癌的淋巴结转移、浸润深度和Dukes分期呈正相关,与分化程度呈负相关（P〈0.05）;黏蛋白MUC2和MUC3的表达与结直肠癌的淋巴结转移、浸润深度和Dukes分期呈负相关（P〈0.05）,而与分化程度无关（P〉0.05）。结论：黏蛋白MUC1的表达上调和MUC2、MUC3的表达下调可能在结直肠癌的发生发展中发挥重要作用,因此黏蛋白MUC1、MUC2、MUC3可成为大肠癌的肿瘤标志物之一,对预后的判断有重要意义。

Expression and Clinical Significance of MUC1 MUC2 and MUC3 in Colorectal Neoplasm

Objective：To study the relationship between expressions of MUC1, MUC2 and MUC3 in colorectal neoplasm and clinicopathological parameters. Methods：The expression of MUC1, MUC2 and MUC3 in 60 cases of colorectal neoplasm and surrounding non - cancerous tissue were detected by immunohistochemistry （IHC）. Results： The positive expression rates of MUC1, MUC2 and MUC3 in surrounding noncancerous tissue were 11.7 %, 100 %, 100 %, respectively; The positive expression rates of MUC1, MUC2 and MUC3 in col- orectal neoplasm tissue were 46.7 % ,60.0 %, 53.3 %, respectively. The expression of MUC1 was positive correlated to lymph node metastasis, depth of invasion and Dukes staging, but negative correlated to the degree of differentiation（P 〈 0.05） ; The expression of MUC2 and MUC3 were positive correlated to lymph node metastasis, depth of invasion and Dukes staging（ P 〈 0.05）, but unrelated to differentiation（P 〉 0.05）. Conclusion： The up - regulation of MUC1 expression or down - regulation of MUC2 and MUC3 expression may be involved in carcinogenesis and progression in colorectal neoplasm, and the expression of MUC1, MUC2 and MUC3 may be new markers , which is very important to predict the prognosis.