| CD44v6在肺癌组织中的表达及意义 |
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| 引用本文： | 仲宁,郑世营,陈锁成. CD44v6在肺癌组织中的表达及意义[J]. 江苏医药, 2005, 31(3): 164-166 |
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| 作者姓名： | 仲宁 郑世营 陈锁成 |
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| 作者单位： | 212002,镇江市第四人民医院心胸外科;212002,镇江市第四人民医院心胸外科;212002,镇江市第四人民医院心胸外科 |
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| 摘 要： | 目的研究CD44v6在肺癌的表达及其意义.方法用免疫组织化学进行CD44v6在肺癌组织、癌旁组织及正常肺组织的免疫组织化学标记,并分析其与肺癌分期、类型及淋巴结转移之间的关系.结果CD44v6在肺癌组织中表达显著高于癌旁组织,在非小细胞肺癌中表达显著高于小细胞肺癌,与临床病理分期(PTNM分期)呈显著正相关,有淋巴结转移组显著高于无淋巴结转移组.结论肺癌组织中的CD44v6高表达与肺癌的发生发展、淋巴结转移及预后有一定的关系.检测CD44v6在肺癌中的表达,可作为判断肺癌淋巴结转移潜能及预后的一个指标.
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| 关 键 词： | 肺癌 CD44v6 免疫组织化学 |
| 修稿时间： | 2004-02-25 |
Expression and significance of CD44 variant exon 6 in lung cancers |
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| ZHONG Ning,ZHENG Shiying,CHEN Suocheng. Expression and significance of CD44 variant exon 6 in lung cancers[J]. Jiangsu Medical Journal, 2005, 31(3): 164-166 |
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| Authors: | ZHONG Ning ZHENG Shiying CHEN Suocheng |
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| Abstract: | Objective To study the expression and significance of CD44v6 in lung cancer(LC).Methods The expression of CD44v6 was detected by immunohistochemical method in 60 patients with lung cancer and 20 cases of normal lung tissues.Its correlations with clinical stages,pathological types,metastatic states of lymph nodes were studied.Results The expression of CD44v6 in the tissues of LC was significantly higher than that in the paracancer.The rate of positive expression of CD44v6 had a significant relationship with PTNM and lymph node metastasis in the tissues of LC.Conclusion The high expression of CD44v6 may have a correlation with the development and lymph node metastasis and prognosis of lung cancer.The expression of CD44v6 may be as a guideline for predicting the potentiality of lymph node metastasis and prognosis in patients with lung cancer. |
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| Keywords: | Lung cancer CD44v6 Immunohistochemistry |
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