Fate of nigrostriatal neurons in young mature mice given 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A neurochemical and morphological reassessment |
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| Authors: | George A Ricaurte J William Langston Louise E Delanney Ian Irwin Stephen J Peroutka Lysia S Forno |
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| Institution: | 1. Department of Neurology, Stanford University School of Medicine, Stanford, CA , USA;2. Department of Neurology, Santa Clara Valley Medical Center, San Jose, CA, USA;3. The Institute for Medical Research, San Jose, CA, USA;4. Department of Pathology, Veterans Administration Medical Center, Palo Alto, CA, U.S.A.;1. School of Bioscience, Indian Institute of Technology, Kharagpur 721302, India;2. Division of Molecular Medicine, Bose Institute, Kolkata 700054, India;3. Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University, Jadavpur, Kolkata 700032, India;1. Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA;2. Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA;3. Neuroscience IDP Program, Stanford University School of Medicine, Stanford, CA 94305, USA;4. Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, CA 94304, USA;5. Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, San Francisco, CA 94143, USA;6. The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, CA 94143, USA;1. Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 24341, Republic of Korea;2. Department of Anatomy and Cell Biology, Medical School, Kangwon National University, Chunchon 24341, Republic of Korea;3. Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea;4. Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea;5. Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University, Seoul 05029, Republic of Korea;6. Laboratory of Biochemistry and Molecular Biology, Department of Medical Technology, Niigata University, Niigata, Niigata 950-2181, Japan;7. Advanced Diagnostic System, Research Laboratory, Fujita Health University Graduate School of Health Science, Toyoake, Aichi 470-1192, Japan;8. Section of Prophylactic Pharmacology, Kanazawa University Venture Business Laboratory, Kanazawa, Ishikawa 920-1192, Japan |
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| Abstract: | The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on nigrostriatal dopaminergic neurons in the mouse was re-examined in view of recent conflicting reports regarding the neurotoxic effect of MPTP in this experimental animal. It was found that while MPTP destroyed a substantial number of dopaminergic nerve terminals in the striatum of young mature (6-8 weeks old) mice, it left the majority of cells in the pars compacta of the substantia nigra (SNc) unaffected. It was also found that 5 months after MPTP treatment there was substantial, although incomplete, recovery of striatal DA nerve terminal markers (DA level, metabolites, uptake, 3H]mazindol binding). Given these observations, it is concluded that while the young mature MPTP mouse may not be a valid animal model of Parkinson's disease (since it does not develop severe SNc cell loss characteristic of this disorder), it will be valuable for the study of how MPTP destroys dopaminergic nerve terminals and may prove useful as an experimental system for studying recovery of dopaminergic fibers after injury and for exploring ways to accelerate this recovery. |
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| Keywords: | dopamine neurotoxicity substantia nigra striatum Parkinson's disease |
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