Dynamics of chromosomal aberrations in male mice of various strains during aging |
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| Authors: | Rozenfel'd S V Togo E F Mikheev V S Popovich I G Zabezhinskii M A Anisimov V N |
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| Affiliation: | (1) Department of Biology and Genetics, I. P. Pavlov St. Petersburg State Medical University, St. Petersburg;(2) Department of Carcinogenesis and Oncogerontology, N. N. Petrov Institute of Oncology, St. Petersburg |
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| Abstract: | We studied the incidence of chromosome aberrations in bone marrow cells and primary spermatocytes in various mouse strains. Experiments were performed on SAMP mice (accelerated aging), control SAMR mice, and long-living CBA and SHR mice. Experiments revealed a positive correlation between the age and the incidence of mutations in their somatic cells and gametes. |
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| Keywords: | chromosomel aberrations aging interstrain differences mice |
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