高尿酸血症与甲状腺功能异常关系的相关性研究

目的 探讨高尿酸血症与甲状腺功能异常的关系.方法 调查10 405名21～89岁某石化企业员工人群,询问甲状腺疾病的手术、药物治疗史,检测血促甲状腺素(TSH)、游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FV3)和血尿酸(SUA).结果 ①该人群中高尿酸血症总患病率17.9%,男性22.6%,女性7.1%.②甲状腺疾病总体知晓率1.7%,男性0.9%,女性3.5%.③10 232名否认甲状腺疾病史者中,甲状腺功能异常总患病率4.2%,男性2.9%,其中TSH降低者0.4%,TSH升高者2.5%;女性7.2%,其中TSH降低者0.9%,TSH升高者6.3%.④与TSH正常组相比,不论性别,TSH升高组的血尿酸均显著升高(P<0.05),aSH降低组的血尿酸无显著变化.⑤TSH升高是高尿酸血症的独立影响因素(OR值男性为1.61、女性为1.72,P<0.01).结论 高尿酸血症患病率与TSH升高显著相关,临床或亚临床甲状腺功能减退症可能是高尿酸血症的危险因素.

Relationship between the prevalence of hyperuricemia and thyroid dysfunction

Objective To study the relationship between the prevalence of hyperuricemia and thyroid dysfunction. Methods 10 405 active and retired workers aged 21 to 89 years in a Petrochemical Corporation in Ningho area of Zhejiang Province were included. Serum thyroid-stimulation hormone (TSH), free thyroxine thyroid diseases, the prevalence of thyroid dysfunction was 4.2%, 2.9% in male and 7.2% in female. The percentage of subjects with low TSH concentration was 0.4% in male and 0.9% in female,the percentage of TSH subjects,the serum uric acid was significantly increased in subjects with high TSH (P<0.05) and not an independent factor associated with hyperuricemia (OR=1.61 for male and 1.72 for female, P value was less than 0.01 for both). Conclusion The prevalence of hyperuricemia is significantly associated with increased TSH concentration. Overt or subclinical hypothyroidism may be risk factors for hyperuricemia.