Ghrelin and Obestatin Levels in Severely Obese Women Before and After Weight Loss After Roux-en-Y Gastric Bypass Surgery |
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Authors: | Christian L Roth Thomas Reinehr Gerit-Holger Schernthaner Hans-Peter Kopp Stefan Kriwanek Guntram Schernthaner |
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Institution: | (1) Seattle Children’s Hospital Research Institute, 1900 Ninth Avenue, Seattle, WA 98101, USA;(2) Vestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, Witten, Germany;(3) Department of Medicine II, Division of Angiology, Medical University of Vienna, Vienna, Austria;(4) Department of Medicine I, Rudolfstiftung Hospital Vienna, Vienna, Austria;(5) Department of Surgery, Rudolfstiftung Hospital Vienna, Vienna, Austria |
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Abstract: | Background Ghrelin and obestatin are derived from the same gene but have different effects: Ghrelin stimulates appetite, and previous—albeit
inconsistent—data show that obestatin may be involved in satiety. The present study was designed to test the hypothesis that
Roux-en-Y gastric bypass (RYGB) surgery and/or the weight loss that reliably results from this procedure would alter levels
of ghrelin and obestatin and ghrelin/obestatin ratios in a cohort of morbidly obese women.
Methods This is a longitudinal follow-up study in 18 morbidly obese women (mean weight 131.2 kg, mean body mass index BMI] 47.4).
Clinical parameters and fasting serum concentrations of ghrelin, obestatin, triglycerides, low-density lipoprotein cholesterol,
glucose, and insulin were measured before and 2 years after RYGB surgery, which was associated with body weight reductions
of 41.5 ± 11.6 kg (mean 62.5% excess weight loss).
Results Ghrelin concentrations (−12%, p = 0.022) and ghrelin/obestatin ratios (−14%, p = 0.017) were lower after surgery than before, while obestatin levels did not change. Changes in ghrelin concentrations correlated
with changes in insulin levels (r = 0.45, p = 0.011). Most cardiovascular risk factors studied improved postsurgically (p < 0.01).
Conclusion In contrast to previous weight loss studies involving gastric banding, ghrelin levels decreased and obestatin levels remained
stable after massive weight loss in long-term follow-up. The favorable gastrointestinal hormone profiles observed are likely
to contribute to the long-term weight loss success rate attributed to RYGB.
C.L. Roth and T. Reinehr contributed equally to this work. |
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Keywords: | Ghrelin Obestatin Gastric bypass Cardiovascular risk factors Obesity Weight loss Roux-en Y gastric bypass |
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