F波对糖尿病周围神经病诊断的意义

目的：研究糖尿病患者及健康人F波，探讨其对诊断糖尿病周围神经病(DPN)的意义。方法：检测68例糖尿病患者和41例健康人上肢正中神经和下肢胫神经F波，检测参数包括F波最短潜伏期(Flmi)，潜伏期离散度(Fchd)、F波传导速度(Fwcv)、F比值(Fratio)。结果：病例组中糖尿病周围神经病变53例，其Flmi、Fchd、Fwcv及Fratio与健康组比较均差异有显著性。F波各参数异常率普遍较高(32．1％～66．0％)，总阳性率为79．2％；糖尿病无周围神经病变15例，其中Fchd增加4例、Flmi延长2例、FWCV减慢2例。结论：F波是诊断糖尿病周围神经病的敏感指标，并可发现亚临床病变，多个参数相结合有助于提高阳性检出率。

Diagnostic Value of F Wave to Diabetic Peripheral Neuropathy

Objective:To evaluate the diagnostic value of F wave in diabetic peripheral neuropathy (DPN) by comparing the difference in F wave between diabetes mellitus and healthy subjects. Methods:F waves of the median and tibial nerves were measured in 68 patients with diabetes mellitus and 41 healthy persons. F latency minimum (Flmi), F chronodispersion (Fchd), F wave conduction velocity (Fwcv) and F ratio were analyzed. Results:In the 53 patients with DPN, Flmi, Fchd, Fwcv and F ratio were significantly different from those in the control group. The abnormality rates of all F wave parameters were high (32.1 % to 66.0 %) and the whole abnormality rate was 79.2 %. In the 15 patients with diabetes mellitus but without peripheral neuropathy, there were 4 cases with increased Fchd, 2 cases with prolonged Flmi and 2 cases with decreased Fwcv. Conclusion: F wave parameters are sensitive indexes to the diagnosis of DPN, and may be used to detect subclinical DPN. Combined use of all F wave parameters can improve the diagnostic sensitivity.