中期因子midkine在妊娠滋养细胞疾病中表达的临床意义

目的 通过分析中期因子在正常绒毛组织、葡萄胎、侵蚀性葡萄胎及绒癌中表达的差异性,探讨中期因子与绒毛膜癌侵袭转移能力的关系.方法 采用免疫组化（SP）法检测正常早孕绒毛组织20例、葡萄胎组织35例、侵蚀性葡萄胎18例和绒毛膜癌12例中MK蛋白的表达情况及差异.结果 免疫组化检测表明MK蛋白在正常早孕绒毛、葡萄胎、侵蚀性葡萄胎以及绒毛膜癌组织中均有表达且主要定位于胞质及包膜,且绒毛膜癌组织中的MK的表达明显强于侵葡组织;侵葡组织中MK的表达明显强于葡萄胎组织,葡萄胎组织中MK的表达又明显强于正常早孕绒毛组织.结论 MK在绒癌细胞中的表达明显强于在正常绒毛组织中的表达,MK在正常早孕绒毛组织、葡萄胎、侵蚀性葡萄胎以及绒毛膜癌中均有表达,且表达逐渐增强.

Clinical Significance of Midkine Expression in Gestational Trophoblastic Disease

Objective To explore the relationship of midkine and choriocarcinoma invasion and metastasis through the analysis of midkine in normal villi,mole,invasive mole and choriocarcinoma expression differences.Methods Immunohistochemical method （SP） was used to detect the expression of choriocarcinoma MK protein in 20 cases of normal villi,35 cases of molar tissue,18 cases of invasive mole and 12 cases.Results Immunohistochemical analysis showed that MK protein was expressed in normal chorionic villi,mole,invasive mole and choriocarcinoma tissue and mainly localized in the cytoplasm and envelope,and MK expression of choriocarcinoma tissue was significantly stronger than the invasion of Portugal organizations in MK expression invasion of Portuguese organizations was significantly stronger than the mole tissue,and MK expression of the molar tissue was stronger than normal villi.Conclusion MK choriocarcinoma cell expression was significantly stronger than the expression in normal villi.MK normal villi,mole,invasive mole and choriocarcinoma were expressed,and the expression gradually increased.