扩张型心肌病患者心房颤动发生与血尿酸水平的关系研究

目的 探讨扩张型心肌病患者心房颤动（房颤）发生与血尿酸水平之间的关系.方法 选择2010年1月～ 2013年5月在笔者医院住院的扩张型心肌病患者152例作为研究对象,按不伴房颤、伴阵发性房颤或伴持续性房颤分为3组,记录3组患者的年龄、心血管相关病史、入院时血压和心功能情况及血尿酸水平.结果 3组患者性别构成、年龄、左心房内径、左心室舒张末期内径、左心室射血分数比较均无统计学差异（P＞0.05）;不伴房颤组、伴阵发性房颤组和伴持续性房颤组血尿酸水平分别为223±24、269±35、314±38 μmol/L,各组之间比较差异具有统计学意义（P＜0.05或P＜0.01）;初发房颤患者、房颤病史在1年以内和1年以上血尿酸水平分别为284±31、297±29、279±25μmol/L,差异均无统计学意义（P＞0.05）.结论 单纯扩张型心肌病、扩张型心肌病伴阵发性房颤、扩张型心肌病伴持续性房颤动血尿酸水平逐渐升高,提示了炎症和氧化应激可能参与了扩张型心肌病所伴心房颤动的发生.

The Atrial Fibrillation in Dilated Cardiomyopathy Patients is Associtaed with the Level of Serum Uric Acid

Objective This study was designed to investigate the relationship between the level of blood uric acid and atrial fibrillation in dilated cardiomyopathy （DCM）.Methods The levels of blood uric acid,LAD and EF in 152 DCM patients with or without atrial fibrillation were observed.Results In DCM patients,the level of blood uric acid in paroxysmal or persistent atrial fibrillation group was higher than that without atrial fibrillation group （P ＜ 0.05 or P ＜ 0.01）,and the level of blood uric acid in persistent atrial fibrillation group was higher than paroxysmal atrial fibrillation group （P ＜ 0.05）.There were no significant difference in blood uric acid among the DCM patients with different history of atrial fibrillation（P ＞ 0.05）.Conclusion The level of blood uric acid was gradually elevated in DCM patients without atrial fibrillation,with paroxysmal and persistent atrial fibrillation.Inflammation and oxidative stress may be involved in atrial fibrillation occurred in dilated cardiomyopathy patients.