去窦弓神经对大鼠脑细胞线粒体离子泵的影响 |
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引用本文: | 胡庆,杨丽军,张山起,李淑贞,杨艳梅,顾宇,刘娜. 去窦弓神经对大鼠脑细胞线粒体离子泵的影响[J]. 中医药研究, 2014, 0(2): 227-228 |
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作者姓名: | 胡庆 杨丽军 张山起 李淑贞 杨艳梅 顾宇 刘娜 |
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作者单位: | [1]沧州医学高等专科学校生理学教研室,061001 [2]河北省沧州市中心医院 ,061001 [3]沧州职业技术学院生物化学教研室,061001 |
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基金项目: | 为河北省沧州市科学技术研究与发展指导计划基金项目(No.1123077ZD) |
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摘 要: | 目的探讨去窦弓神经(SAD)对脑细胞线粒体Na+-K+-ATP酶和Ca2+-ATP酶活性的影响。方法50只大鼠随机分为对照组、假手术组、SAD30d组、SAD60d组、SAD90d组,分别测定脑细胞线粒体Na+-K+-ATP酶、Ca。LATP酶的变化。结果SAD30d组、SAD60d组、SAD90d组Na+-K+-ATP酶和Ca2+-ATP酶活性明显降低(P〈0.01)。结论去窦弓神经使脑细胞线粒体膜的Na+-K’-ATP酶和Ca+-ATP酶活性明显降低,且随时间延长日益明显。
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关 键 词: | 去窦弓神经 线粒体 Na+-K+-ATP酶 Ca+-ATP酶 |
Influence of Sinoaortic Denervation the Ion Pump of Mitochondria of Rats Nerve Cell |
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Affiliation: | Hu Qing,Yang Lijun,Zhang Shanqi,et al//Department of Physiology,Cangzhou Medical College (Cangzhou 061001) |
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Abstract: | Objective To study the influence of sinoaortic denervation on the enzymatic activity of Na+ - K+ - ATP enzyme as well as Ca2+- ATP enzyme of mitochondria of rats nerve cell. Methods Fifty rats were divided into three groups: Control group,experi- mental group,and sham operation group. The Na+- K+- ATP enzyme and Ca2+- ATP enzyme in mitochondria of the rat nerve cell were determined respectively. Results After operation,the enzymatic activity of Na+ - K+ - ATP enzyme as well as Ca2+- ATP en- zyme was decreased obviously at 30 days, 60 days ,and 90 clays (P〈0.01). Conclusion Sinoaortic denervation could reduce the ac- tivity of Na+-K+- ATP enzyme and Ca2+- ATP enzyme in mitochondrial membrane of rat nerve cell,and the effect became more evi- dent over time. |
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Keywords: | sinoaortic denervation mitoehondria Na+ - K +- ATP enzyme Ca2+ - ATP enzyme |
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