| 去窦弓神经对大鼠脑细胞线粒体离子泵的影响 |
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| 引用本文： | 胡庆,杨丽军,张山起,李淑贞,杨艳梅,顾宇,刘娜.去窦弓神经对大鼠脑细胞线粒体离子泵的影响[J].中医药研究,2014(2):227-228. |
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| 作者姓名： | 胡庆 杨丽军 张山起 李淑贞 杨艳梅 顾宇 刘娜 |
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| 作者单位： | [1]沧州医学高等专科学校生理学教研室,061001 [2]河北省沧州市中心医院 ,061001 [3]沧州职业技术学院生物化学教研室,061001 |
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| 基金项目： | 为河北省沧州市科学技术研究与发展指导计划基金项目（No.1123077ZD） |
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| 摘 要： | 目的探讨去窦弓神经（SAD）对脑细胞线粒体Na＋-K＋-ATP酶和Ca2＋-ATP酶活性的影响。方法50只大鼠随机分为对照组、假手术组、SAD30d组、SAD60d组、SAD90d组，分别测定脑细胞线粒体Na＋-K＋-ATP酶、Ca。LATP酶的变化。结果SAD30d组、SAD60d组、SAD90d组Na＋-K＋-ATP酶和Ca2＋-ATP酶活性明显降低（P〈0．01）。结论去窦弓神经使脑细胞线粒体膜的Na＋-K’-ATP酶和Ca＋-ATP酶活性明显降低，且随时间延长日益明显。
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| 关 键 词： | 去窦弓神经 线粒体 Na＋-K＋-ATP酶 Ca＋-ATP酶 |
Influence of Sinoaortic Denervation the Ion Pump of Mitochondria of Rats Nerve Cell |
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| Institution: | Hu Qing,Yang Lijun,Zhang Shanqi,et al//Department of Physiology,Cangzhou Medical College (Cangzhou 061001) |
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| Abstract: | Objective To study the influence of sinoaortic denervation on the enzymatic activity of Na＋ - K＋ - ATP enzyme as well as Ca2＋- ATP enzyme of mitochondria of rats nerve cell. Methods Fifty rats were divided into three groups： Control group,experi- mental group,and sham operation group. The Na＋- K＋- ATP enzyme and Ca2＋- ATP enzyme in mitochondria of the rat nerve cell were determined respectively. Results After operation,the enzymatic activity of Na＋ - K＋ - ATP enzyme as well as Ca2＋- ATP en- zyme was decreased obviously at 30 days, 60 days ,and 90 clays （P〈0.01）. Conclusion Sinoaortic denervation could reduce the ac- tivity of Na＋-K＋- ATP enzyme and Ca2＋- ATP enzyme in mitochondrial membrane of rat nerve cell,and the effect became more evi- dent over time. |
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| Keywords: | sinoaortic denervation mitoehondria Na＋ - K ＋- ATP enzyme Ca2＋ - ATP enzyme |
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