CA125与扩张型心肌病心功能不全相关性研究

目的 探讨扩张型心肌病患者血清CA125水平与心功能、左心室舒张末期内径（LVEDd）及左心室射血分数（LVEF）的关系.方法 对76名NYHA分级Ⅲ～Ⅳ级的扩张型心肌病患者进行分组,心功能Ⅲ级为Ⅲ级组,心功能Ⅳ级为Ⅳ级组,另选30例作为健康对照组,其中Ⅲ级组与Ⅳ级组给予抗心力衰竭药物治疗4周,对照组未予处理,分别测定治疗前后患者血清CA125浓度、LVEDd及LVEF大小并比较其变化,对CA125的浓度与LVEDd、LVEF进行相关性分析.结果 心力衰竭程度越严重,血清CA125越高,LVEDd越大,LVEF越低,心力衰竭好转后,上述指标改善明显（P＜0.05）,其中Ⅳ级组CA125浓度及LVEDd仍高于Ⅲ级组,LVEF仍低于Ⅲ级组.CA125浓度与LVEDd呈正相关,与LVEF呈负相关（P＜0.01）.结论 血清CA125水平与心力衰竭严重程度相关,可用于扩张型心肌病患者心功能不全的辅助诊断及预后评估.

Relationship between CA125 and Cardiac Dysfunction in Dilated Cardiomyopathy Patients

Objective To investigate the relationship between the serum level of CA125 and the heart function in patients with dilated eardiomyopathy（DCM） , left ventricular end diastolic diameter （LVEDd） and left ventricular ejection fraction （LVEF） also were he studied. Methods A total of 76 DCM patients of NYHA gradeⅢ～Ⅳ were divided 3 groups. The NYHA in level m was named group m ,and the NYHA in level Ⅳ was named group IV. Another 30 cases were chosen as healthy control group. The group and group Ⅳ were given anti heart failure drug treatment for 4 weeks. The control group were given no treatment. Respectively before and after treatment the serum CA125, LVEDd and LVEF size were compared, then a correlation analysis between the CA125 level and LVEDd, LVEF was made. Results The higher degree of heart failure, the higher serum CA125, bigger LVEDd, lower LVEF. When the heart function was improved, the index improved significantly （P 〈 0. 05）. The CA125 level and LVEDd was higher in group IV than those of groupⅢ. LVEF was lower in group IV than that of group Ⅲ. The concentration of CA125 had positive correlation with the LVEDd, negative correlation with the LVEF （ P 〈 0.01 ）. Conclusion Serum CA125 level was associated with the severity of heart failure, which can be used for assistant diagnosis and prognosis evaluation of cardiac function in patients with dilated cardiomyopathy.