糖尿病视网膜病变大鼠模型的实验研究

目的 建立和评价链脲佐菌素（STZ）诱导的糖尿病视网膜病变大鼠模型.方法 用链脲佐菌素建立糖尿病大鼠模型,分为空白对照组、糖尿病组（1、3、5个月）,进行HE染色和电镜观察,测定视网膜神经节细胞平均个数.结果 糖尿病组大鼠出现血糖明显升高,组织学显示出现明显的糖尿病视网膜病变.视网膜神经节细胞平均个数：与空白对照组比较,糖尿病1个月组和糖尿病3个月组差异有统计学意义（P＜0.05）;糖尿病5个月组差异有统计学意义（P ＜0.000）.结论 链脲佐菌素诱导的糖尿病大鼠视网膜病变模型可以成为糖尿病视网膜病变研究的动物模型.

Experimental Study of Diabetic Retinopathy Rat Model

Objective To establish and observe the diabetic retinopathy rats model by STZ.Methods Sixty male rats were randomly divided into control group,1 month diabetic group,3 month diabetic group and 5 month diabetic group.Diabetic rats were induced by the injection of streptozocin （60mg/kg）.The pathogenic changes of diabetic retinopathy was observed.Results Blood glucose level obviously rose and diabetic retinopathy was seen in the diabetic group rats.Compared with normal group,there was difference in the Average value in the retinal ganglion cells 1 month inthg diabetic group and 3 month diabetic group （P ＜ 0.05） ; there was markedly difference in the 5 month diabetic group （P ＜ 0.000）.Conclusion The diabetic retinopathy rats model by in duced STZ can be used in diabetes retinopathy studies.