骨化三醇联合仙灵骨葆治疗女性骨质疏松症的临床研究

目的通过骨化三醇联合仙灵骨葆、阿仑膦酸钠分别治疗女性症状型骨质疏松症患者，对比骨密度、疼痛感觉、碱性磷酸酶指标改善情况观察其疗效，考察骨化三醇联合仙灵骨葆对骨质疏松症具体临床效果，提供临床参考。方法选取河北省徐水县原发性骨质疏松症女性患者90人，随机分为两组，每组45人，分别使用骨化三醇胶丸＋仙灵骨葆胶囊（A组），阿仑膦酸钠（B组）治疗6个月，对比骨密度、疼痛感觉、碱性磷酸酶指标改善情况。结果A组完成治疗38人，B组完成治疗36人；两组治疗6个月后骨密度、疼痛感觉、碱性磷酸酶指标均明显改善（P〈0．05），两组比较差异无统计学意义（P〉0．05），两组个别患者出现药物不良反应，均程度较轻，停药后症状可逆，但是联合用药组有更好的患者依从性。结论骨化三醇胶丸联合仙灵骨葆胶囊治疗女性骨质疏松症有良好疗效。

Clinical Study of Calcitriol Combined with Xianlinggubao in the Treatment of Women with Osteoporosis.

Objective To explore the clinical effects of Calcitriol combined with Xianlinggubao in the treatment of women with osteo- porosis by determination in alendronate, honedensity contrast, the feeling of pain, alkaline phosphatase indicators and provide clinical ref- erence. Methods Ninty female patients with primary osteoporosis in Xushui county of Hebei province were randomly divided into 2 groups, each group consisted of 45 people respectively, the patients in group A were treated with Calcitriol Soft Capsules ＋ Xianlinggubao capsule, the patients in group B were treated with alendronate sodium. After treating for 6 months, the bone mineral density, alkaline phosphatase enzymes, and the feelings of pain were examined and analyzed. Results The results indicated that the bone density, the feeling of pain, alkaline phosphatase indexes were significantly improved in all the patients who were received the treatment for 6 months （ P 〈 O. 05 ）. There was no significant differences between the 2 groups （ P 〉 0.05 ） , some individual patients had adverse drug reactions, the degrees were not serious, the side effects could disappeared soon after stopping taking the medicines, but the patients received com- bined treatment had better patient compliance. Conclusion There are significant effects of Calcitriol soft capsules combined with Xian- linggubao capsule in the treatment of women patients with osteoporosis.