X线立体定向放射治疗脑转移瘤的疗效分析

目的观察立体定向放射手术治疗脑转移瘤的疗效。方法X线立体定向放射治疗脑转移瘤患者47例，采用10MV的直线加速器多个非共面弧旋转照射，肿瘤剂量为18～25Gy(平均22.1Gy)。40例患者在术后接受了肿瘤剂量30～40Gy的全脑放疗。结果中位生存期为11个月，1年生存率37.5%，疗后3个月的肿瘤控制率为90.7%，KPS≥70、原发肿瘤已控和无颅外转移患者的预后较好(P<0.05)。结论立体定向放射治疗脑转移瘤是安全和有效的。

X-ray stereotactic radiosurgery for brain metastases

Objective　To evaluate the effectiveness of X-ray stereotactic radiosurgery (SRS) for brain metastases.Methods　Retrospective analysis of 47 patients with brain metastases who underwent SRS un der a 10 MV linear accelerator was carried out.Tumor diameter varied from 12 mm t o 40 mm (mean 27mm ).Tumor dose varied from 18～25Gy (mean 22.1Gy).Fractionated whole brain ra diotherapy was delivered to 40 patients after SRS.32 patients were examined by CT and (or) MRI.Results　Median survival from SRS was 11 months.Tumor control rate was 90.7% after SRS.Tu mor complete response rate was 68.8%.Tumor recurrence was found by CT or MRI.The re was longer survival in KPS≥70,primary tumor was controlled and no extracrani al metastases was found.The main complication was brain edema(18.8%).Conclusion　The results of this report shows that SRS is an effective and safe treatment option.