| 人参皂苷Rg1的溶解特性与脂质体包封率关系的研究 |
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| 引用本文： | 陈新梅,朱家壁. 人参皂苷Rg1的溶解特性与脂质体包封率关系的研究[J]. 中国药房, 2007, 18(1): 41-43 |
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| 作者姓名： | 陈新梅 朱家壁 |
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| 作者单位： | 1. 山东中医药大学药学院,济南市,250014
2. 中国药科大学药物制剂研究所,南京市,210009 |
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| 基金项目： | （致谢：Dr.Xinhua.Chen（The 0ld Dominion University,Norfolk,Virginia,US）和Dr.Yonggang Chen（University of London,London,UK）给予资金支持和鼓励） |
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| 摘 要： | 目的:研究人参皂苷Rg1油-水分配系数与脂质体包封率的关系。方法:测定人参皂苷Rg1的正辛醇-水分配系数、氯仿-水分配系数,人参皂苷Rg1在水、甲醇、乙醇中的溶解度;采用不同的方法制备脂质体并测定包封率。结果:人参皂苷Rg1油-水分配系数低于0.5,在3种溶剂中微溶;几种制备方法所得人参皂苷Rg1脂质体包封率均较低。结论:人参皂苷Rg1油-水分配系数小,不适合制成脂质体。
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| 关 键 词： | 人参皂苷Rg1 溶解度 油-水分配系数 包封率 |
| 文章编号： | 1001-0408（2007）01-0041-03 |
| 收稿时间： | 2006-01-17 |
| 修稿时间： | 2006-03-04 |
On Solubility of Ginsenoside Rg1 and Liposome Entrapment Efficiency |
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| CHEN Xinmei,ZHU Jiabi. On Solubility of Ginsenoside Rg1 and Liposome Entrapment Efficiency[J]. China Pharmacy, 2007, 18(1): 41-43 |
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| Authors: | CHEN Xinmei ZHU Jiabi |
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| Abstract: | OBJECTIVE:To study the correlation between the oil-water partition coefficient of the ginsenoside Rg1 and liposome entrapment efficiency.METHODS:N-octyl alcohol-water partition coefficient,chloroform-water partition coefficient of ginsenoside Rg1,and its dissolubilities in distilled water,methyl alcohol and ethanol were determined.Different methods were used to prepare ginsenoside Rg1 liposome and its entrapment efficiencies were determined.RESULTS:The oil-water partition coefficient of ginsenoside Rg1 was lower than 0.5,and which was slightly soluble in 3 solvents;The liposome entrapment efficiencies of ginsenoside Rg1 prepared by different methods were all low.CONCLUSION:Ginsenoside Rg1 showed low partition coefficient and thus unsuitable to be made into liposome. |
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| Keywords: | Ginsenoside Rg1 Solubility Oil-water partition coefficient Entrapment efficiency |
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