| Abstract: | Activity of Na,K-ATPase, acetylcholinesterase (AChE), and glutamate decarboxylase (GDC) was investigated in fractions of the rat brain and spinal cord during and 5 and 30 min after a single electric shock. GDC activity of the brain  synaptosomes was reduced but not significantly, whereas activity of AChE, Na,K-ATPase and, probably, proteolytic enzymes was increased 5 min after electric shock and returned to normal after 30 min. It is suggested that inhibition of Na,K-ATPase activity in the synaptosomes of the rat cerebral cortex may play a role in the pathogenesis of convulsions.Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. Kemerovo Medical Institute. (Presented by Academician of Medical Sciences of the USSR G. N. Kryzhanovskii.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 86, No. 8, pp. 139–142, August, 1978. |
