乙肝病毒携带产妇乳汁中乙肝病毒携带情况分析

目的 :分析乙型肝炎病毒携带产妇乳汁中乙肝病毒 (HBV)携带情况以及探讨母乳喂养的安全性问题。方法 :随机抽取 6 2例孕期检测有一项以上乙肝血清学指标 (HBVM)阳性且肝功能正常产妇及 10例乙肝标志物阴性的健康产妇作对照 ,采用PCR技术检测其初乳中的HBV -DNA ,并与血清乙肝标志物的检测结果进行比较。结果 :6 2例HBVM阳性产妇中有 35例检出HBV -DNA(5 6 5 % ) ,而对照组中无一例阳性。HBeAg阳性组产妇初乳排毒率明显高于HBeAg阴性组 ,有显著性差异(P <0 0 1)。结论 :对乙肝标志物阳性产妇 ,除对新生儿加强免疫外 ,还应检测其乳汁中的HBV -DNA。若乳汁中HBV -DNA阳性 ,则不以母乳喂养为好

Detection of HBV- DNA in the colostra from hepatitis B virus markers seropositive carrier mothers by PCR

Objective:To investigate the safety of breast-feeding of hepatitis B virus markers(HBVM) seropositive carrier mothers.Methods:62 HBVM seropositive carrier mothers and 10 normal controls were recruited.HBV-DNA was detected by PCR in the colostra.Results:The rate of HBV-DNA positive in the samples from mothers who were HBVM seropositive carrier was 56 5%,HBV-DNA was not found in the control group.The positive rate in HBeAg(+) group was higher than that in HBeAg(-) group,there was a significant difference(P<0 01).Conclusion:HBV-DNA should be detected in the milk from mothers who were HBVM positive carrier,The infants born to mothers who were HBVM positive should be intensified immunoprotection.If HBV-DNA in the milk was positive,breast feeding by an HBVM positive mother should be discouraged.