基质溶解素-1基因启动子多态性与急性心肌梗死的相关性

目的：研究中国南方人群基质溶解素-1基因启动子1612 5A／6A多态性与急性心肌梗死的相关性。方法：采用DNA测序法检测116例急性心肌梗死患者和105例对照的基质溶解素-1基因启动子序列。结果：①基质溶解素-1基因启动子1612 5A／6A多态性的三种基因型（5A／SA、5A／6A、6A／6A）符合Hardy—Weinberg分布。②与对照组相比，心梗组的基质溶解素-1基因5A／SA和5A／6A基因型较多见，差异有显著性，P〈0．01。③基因型的相对风险分析发现，5A／SA或5A／6A基因型携带者惠急性心肌梗死风险是6A／6A基因型的3．050倍（95%可信区间：1．653—5．627）。结论：基质溶解素-1基因启动子16125A／6A多态性可能与中国南方急性心肌梗死的遗传易感性相关联，5A等位基因是急性心肌梗死发病的一个独立危险因素。

Correlative research between polymorphisms of stromeIysin-1 promoter 1612 5A/6A and acute myocardiaI infarction

Objective： To investigate the relationship between the polymorphism of 1 612 5A/6A in the promoter of the stromelysin-1 gene and the acute myocardial infarction （AMI） in population of southern Chinese. Methods： Using DNA sequencing, the polymorphism of the stromelysin-1 gene was detected in both 116 AMI patients and 105 control subjects. Results： （1） The allelic distribution of the stromelysin-1 gene in both groups matched the Hardy-Weinberg equilibrium （P〉0.05）.（2） The number of 5A allele of the promoter of the stromelysin-1 gene in patients with AMI was higher than that of the control group （P〈0.01）.（3） The odds ratio of the 5A/6A＋SA/SA was 3.050（95% CI, 1.653 to 5.627）. Conclusion： The 1612 5A/6A polymorphism in the promoter of the stromelysin-1 gene is associated with AMI in southern Chinese. The 1612 5A allele in the promoter of the stromelysin-1 gene may play an important role in the pathogenesis of AMI.