| 黄酮类化合物对心肌缺血的保护作用及其构效关系研究 |
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| 引用本文： | 巫志峰,冯星,周畅,周源,刘英姿,杨华中. 黄酮类化合物对心肌缺血的保护作用及其构效关系研究[J]. 湖南师范大学学报(医学版), 2006, 3(4): 26-28 |
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| 作者姓名： | 巫志峰 冯星 周畅 周源 刘英姿 杨华中 |
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| 作者单位： | 广东省中医院中心实验室,广东,广州,510120;湖南师范大学医学院药理教研室,湖南,长沙,410006;长沙医学院,湖南,长沙,410219 |
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| 基金项目： | 湖南师范大学校科研和教改项目 |
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| 摘 要： | 目的:以冠脉结扎诱发大鼠心肌损伤为模型探讨黄酮类化合物对缺血再灌注心肌的保护作用机制。方法:采用MDA、SOD和GSH-Px测定试剂盒分别测定了假手术组、模型对照组以及黄酮给药组的大鼠心肌血清中MDA含量、SOD活性和心肌匀浆中GSH-Px活性。结果:各给药组的SOD和GSH-Px活性均较模型对照组有明显升高,MDA含量明显下降。结论:黄酮类化合物具有抗心肌缺血作用且与结构有密切关系。
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| 关 键 词： | 心肌缺血 黄酮类化合物 丙二醛 超氧化物歧化酶 谷胱苷肽过氧化物酶 |
| 文章编号： | 1673-016x(2006)04-0026-03 |
| 修稿时间： | 2006-11-15 |
Protective Effects of Flavonoids Against Ischemia/reperfusion Injury in Rats and the Research between Structure and Effect |
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| WU Zi-feng,FENG Xing,ZHOU Chang,ZHOU Yuan,LIU Ying-Zhi,YANG Hua-Zhong. Protective Effects of Flavonoids Against Ischemia/reperfusion Injury in Rats and the Research between Structure and Effect[J]. Journal of Hunan Normal University(Medical Science), 2006, 3(4): 26-28 |
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| Authors: | WU Zi-feng FENG Xing ZHOU Chang ZHOU Yuan LIU Ying-Zhi YANG Hua-Zhong |
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| Abstract: | Objective To investigate the effects of flavonoids on ischemia/reperfusion in rats.Methods The injured model was established by ischemia 10 min and reperfused 30 min in rats by LAD-occlusion.The malondialdehyde(MDA),superoxide dismutaes(SOD) of serum and GSH-Px of myocardial homogenate were measured.Results The results showed that flavonoids significantly lowered the content of MDA in serum and increase the activity of SOD and GSH-Px.Conclusion Flavonoids have the effects against ischemia/reperfusion injury in rats,which has the relationship between structure and effect. |
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| Keywords: | ischemia/reperfusion flavonoids MDA SOD GSH-Px |
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