| 胶体金法观察慢性无症状乙型肝炎病毒感染者肝组织内病毒抗原的表达 |
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| 引用本文： | 曹虹,沈淑华,骆抗先,乔世忠,易俊卿.胶体金法观察慢性无症状乙型肝炎病毒感染者肝组织内病毒抗原的表达[J].南方医科大学学报,1988(1). |
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| 作者姓名： | 曹虹 沈淑华 骆抗先 乔世忠 易俊卿 |
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| 作者单位： | 第一军医大学第一附属医院传染科
(曹虹，沈淑华，骆抗先，乔世忠)，广州市传染病医院(易俊卿) |
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| 摘 要： | 用胶体金法对204例慢性无症状HBV感染者肝组织内病毒抗原进行了免疫组织化学研究.慢性无症状肝炎(AsH)与慢性无症状携带者(AsC)的肝组织病变不同,但病毒抗原的检出率却无显著差别;AsH与慢性乙型肝炎(CHB)的肝组织病变近似,但AsH病毒抗原的检出率却显著高于CHB.这可能与慢性无症状HBV感染者对病毒抗原在肝组织内的免疫应答低下有关,而肝组织病变可能是对长期感染的组织反应的累积.
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| 关 键 词： | 乙型肝炎病毒 慢性无症状HBV感染 抗原 肝组织病变 胶体金法 |
Use of colloidal gold probes in studies of the expression of viral antigens in the liver of individuals with chronic asymptomatic hepatitis B virus infection |
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| Cao Hong,et al.Use of colloidal gold probes in studies of the expression of viral antigens in the liver of individuals with chronic asymptomatic hepatitis B virus infection[J].Journal of Southern Medical University,1988(1). |
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| Authors: | Cao Hong |
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| Abstract: | HBV antigens were ilnmunohistochemically demonstrated with colloidal gold probes in the liver of 204 individuals with chronic asymptomatic HBV infection. The results were compared with those of 46 patients with chronic hepatitis type B ( CHB ). It was found that the prevalence of the intrahepatic antigens had no significant difference between chronic asymptomatic hepatitis ( AsH ) and chronic asymptomatic carriers (AsC) ; however, a striking difference did exist between AsH and CHB which had similar liver pathology. HBsAg and HBcAg were 94.2% and 46.2%, respectively in AsH and 32.6% and 17.4% in CHB.These results suggest that the high prevalence of viral antigens in the liver of individuals with chronic asymptomatic HBV infection might be resulted from accumulative changes during a long-term infection. |
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| Keywords: | hepatitis B virus chronic asymptomatic HBV infection viral antigens liver histopathology colloidal gold probe |
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