Sesquiterpene glucosides from anti-leukotriene B4 release fraction of Taraxacum officinale |
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| Authors: | Kashiwada Y Takanaka K Tsukada H Miwa Y Taga T Tanaka S Ikeshiro Y |
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| Affiliation: | a Niigata College of Pharmacy, Niigata, Japanb Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japanc Faculty of Applied Bioscience, Tokyo University of Agriculture, Setagaya-ku, Tokyo, Japan |
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| Abstract: | Chemical examination of the MeOH extract of the root of Taraxacum officinale, which exhibited inhibitory activity on the formation of leukotriene B4 from activated human neutrophils, has resulted in the isolation of 14-O-β-D-glucosyl-11,13-dihydro-taraxinic acid (1) and 14-O-β-D-glucosyl-taraxinic acid (2). The absolute stereostructure of 1 has been established by X-ray chrystallographic examination. |
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| Keywords: | Taraxacum officinale Compositae Anti-leukotriene B4 formation Germacrane Sesquiterpene |
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