Graves'病患者诊治中红细胞微量元素含量的变化

目的 :探讨Graves’病 (GD)患者在诊治中红细胞微量元素 (Zn、Cu、Fe、Se)含量的变化。方法 :采用放射免疫分析 (RIA)、原子吸收分光光谱技术 (AAS)分别检测 4 2例GD患者、2 0例经治疗甲状腺功能恢复至正常水平GD患者与 30名健康人血清甲状腺激素水平和红细胞微量元素含量。结果 :GD组 ,红细胞Zn、Se含量明显降低 ,与对照组比较有显著性差异 (p <0 0 1 ) ;红细胞Cu、Fe明显升高 ,与对照组比较有显著性差异 (p<0 0 1 ,p <0 0 5 ) ;且Zn与FT4呈明显负相关 (r=- 0 5 4 2 ,p <0 0 1 )、Cu与FT4呈明显正相关 (r =- 0 31 1 ,p <0 0 5 )。GD治疗缓解组 ,红细胞Zn、Se水平明显高于初诊未治疗组 ,差异有显著性 (p <0 0 1 ,p <0 0 5 ) ;但Se仍未达到对照组水平 (p <0 0 1 ) ;红细胞Cu、Fe水平明显低于初诊未治疗组 ,差异有显著性 (p <0 0 5 ) ,但Cu未达到对照组水平 (p <0 0 5 )。结论 :GD患者存在红细胞微量元素的含量改变 ,甲状腺激素可能干扰红细胞微量元素的代谢

Changes of Trace Elements in Erythrocytes of Patients with Graves' Disease

Objective To investigate the changes of trace elements (Zn,Cu, Fe, Se) in erythrocytes of patients with Graves' disease (GD). Methods The plasma thyroid hormones levels and the contents of trace elements in erythrocytes were determined with RIA and atom absorption spectrophotometry (AAS) respectively in 42 cases of GD, before trentment 20 cases of GD patients after therapy (in euthyroid state) and 30 normal controls. Results Without treatment the contents of microelements Zn, Se in erythrocytes were significantly lower ( p <0 01) and Cu, Fe were significantly higher ( p<0 01?p<0 05 ) in GD patients than those in normal controls. The content of Zn was negatively correlated to FT 4 ( r=-0 542,p<0 01 ) and Cu was positively correlated to FT 4 levels ( r=0 311,p<0 05 ). The contents of microelements Zn, Se in erythrocytes after treatment were significantly higher ( p<0 01?p<0 05 ) and Cu, Fe were significantly lower ( p<0 05 ) than those before treatment. However, the Se content was still lower and Cu content Still higher than that in the controls ( p<0 01,p<0 05 respectively). Conclusion The trace elements metabolism in erythrocytes might be adversely influenced by excess of thyroid hormones in patients with GD.