儿童急性淋巴细胞白血病的预后因素

目前在西方规模大的儿童急性淋巴细胞白血病（ALL）治疗中心，其ALL的治愈率已达到80%，此成就归因了依据危险度所确定的多药联合化疗和中枢神经系统预防。患的分层是根据预后因素预测复发危险。研究预后因素间的相互关系是必要的，已被广泛熟知的宿主相关因素包括年龄，性别，种族和药物遗传学。疾病相关预后因素包括白细胞计数，免疫分型，细胞或分子遗传学特征。早期治疗反常是最有力的预后因素。大的，对照的和随机的临床方案的采用大大地改善了儿童急性淋巴细胞白血病的预后。

Prognostic Factors of Childhood Acute Lymphoblastic Leukemia

The cure rate for children with acute lymphoblastic leukemia in big treatment centers in Western countries is now about 80%. This accomplishment is owe to patients successful treatment based on combination of multiagent chemotherapy, risk based intensification of therapy and central nerve system prophylaxis. Stratification of patients is according to prognostic factors that predict risk of relapse. It is necessary to consider the interrelationship of prognostic factors. In host related factors, which are generally known as age, gender, race, and pharmacogenetics. Disease related factors include white blood cell count, immunophenotyping, cytogenetic or molecular genetics features, etc. Treatment related factors are what can be modified. Early response to treatment is often the strongest prognostic factor. Large, controlled and usually randomized clinical trials greatly improve the prognosis of childhood acute lymphoblastic leukemia.