Neutrophil as a mediator of ischemic edema formation in the brain |
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| Authors: | Y Shiga H Onodera K Kogure Y Yamasaki Y Yashima H Syozuhara F Sendo |
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| Institution: | Department of Neurology, Tohoku University, School of Medicine, Sendai, Japan. |
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| Abstract: | We investigated the contribution of neutrophils to brain edema formation using a transient focal ischemia model in rats. Rats were given anti-neutrophil monoclonal antibody (RP3) intraperitoneally to deplete circulating neutrophils. In RP3-treated rats, ischemic brain edema formation 1 day after reperfusion was significantly decreased compared to that of saline-treated control rats. We speculate that chemical mediators released by infiltrating neutrophils alter vascular permeability and play an important role in post-ischemic brain edema formation. |
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