109例尖锐湿疣患者的HPV型别特点分析

目的了解尖锐湿疣患者人乳头瘤病毒(human papilloma virus,HPV)感染的型别特点,为疾病的治疗和预后的判断提供理论依据。方法采用流式荧光-液态芯片技术对109例尖锐湿疣患者(男76例,女33例)进行HPV基因型别检测,分析男女患者感染HPV基因型及感染类型特点。结果尖锐湿疣患者的HPV DNA阳性检出率为87.16%,阳性检出率前6位的基因型分别为HPV6、HPV11、HPV16、HPV39、HPV18、HPV51。男女患者之间HPV DNA阳性检出率差异无统计学意义;在HPV感染类型方面,女性多重感染率为78.57%,男性为53.73%,女性明显高于男性(P0.05);在感染型别方面,女性高危型感染率为49.21%,男性为25.20%,女性明显高于男性(P0.05)。结论尖锐湿疣患者感染的HPV以低危亚型、多重感染为主,亦有一定比例的高危型感染。不同性别的尖锐湿疣患者感染HPV的特点有差异,男性患者以低危型别和单一类型感染为主,而女性以高危型别和混合的多重类型感染为主。HPV感染对女性影响要大于男性,要重视对成年女性的HPV的筛查,做到及早发现及早治疗,改善女性的生活质量。

Analysis of HPV type characteristics in 109 patients with condyloma acuminatum

Objective To analyze the characteristics of HPV genotypes of patients infected with condyloma acuminatum (CA) and provide theoretical basis for the treatment and prognosis of diseases. Methods HPV genotype was detected by flow cytometry in 109 CA cases (76 males and 33 females), and the characteristics of HPV genotype and infection type were analyzed. Results The HPV positive rate of CA patients was 87.16%. The main subtypes were HPV6, HPV11, HPV16, HPV39, HPV18 and HPV51. There were no statistically significant differences in the positive rate of HPV between male and female patients (P>0.05); In HPV infection types, the multiple infection rate was 78.57% in female, 53.73% in male, and the multiple infection rate of female was significantly higher than that in male (P<0.05); In HPV infection genotypes, infection rate of high-risk type was 49.21% in female, 25.20% in male, and female’s was significantly higher than that in male (P < 0.05). Conclusions The HPV of patients with CA is mainly low-risk and multiple infection, and there is a certain proportion of high risk type. There are differences in the characteristics of HPV infection among patients with different genders. The infection of male patients is mainly low-risk and single type, and the infection of female patients is mainly high-risk and mixed multiple types .This shows that the impact of HPV infection on women is greater than that of men, so it is necessary to pay much attention to the HPV screening of adult women and to improve their life quality by early detection and early treatment.