| CD4/CD45双色单平台法检测HIV感染者CD4~+ T淋巴细胞研究进展 |
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| 引用本文： | 许亚宁,张辉,肖瑶. CD4/CD45双色单平台法检测HIV感染者CD4~+ T淋巴细胞研究进展[J]. 传染病信息, 2016, 0(3): 176-180. DOI: 10.3969/j.issn.1007-8134.2016.03.014 |
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| 作者姓名： | 许亚宁 张辉 肖瑶 |
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| 作者单位： | 1. 甘肃省疾病预防控制中心, 兰州,730000;2. 中国疾病预防控制中心性病艾滋病预防控制中心, 北京,102206 |
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| 摘 要： | CD4+T淋巴细胞计数是评价AIDS疾病进展和抗病毒治疗效果的重要指标。本文介绍了流式细胞仪CD4+T淋巴细胞计数方法的发展历史。将CD4/CD45双色单平台法的准确性、可靠性和经济性与其他方法进行了比较。表明该法简便、廉价且实用性强。同时介绍了当前适用于CD4/CD45双色单平台法的几款流式细胞仪的机型特点。
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| 关 键 词： | HIV CD4%2BT淋巴细胞计数 抗原,CD45 流式细胞术 |
Research advances in CD4+ T lymphocyte enumeration using two-color CD4/CD45 single-platform protocol in HIV-infected patients |
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| XU Ya-ning,ZHANG Hui,XIAO Yao. Research advances in CD4+ T lymphocyte enumeration using two-color CD4/CD45 single-platform protocol in HIV-infected patients[J]. Infectious Disease Information, 2016, 0(3): 176-180. DOI: 10.3969/j.issn.1007-8134.2016.03.014 |
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| Authors: | XU Ya-ning ZHANG Hui XIAO Yao |
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| Abstract: | CD4+ T lymphocyte count is regarded as a major marker for evaluating disease progression and antiretroviral therapy efficacy in HIV-infected individuals. In this review, the authors introduce the development of CD4+ T lymphocyte enumeration using flow cytometry, and compare CD4/CD45 two-color single-platform protocol with other protocols in terms of accuracy, reliability and economics. CD4/CD45 two-color single-platform protocol is considered to be convenience, cheap and practical. In addition, the authors introduce specific characteristics and performance of various kinds of flow cytometers using CD4/CD45 two-color single-platform protocol for CD4+ T lymphocyte enumeration. |
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| Keywords: | HIV CD4 lymphocyte count antigens,CD45 flow cytometry |
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