GP方案与放疗联合治疗食管癌纵隔淋巴结转移的临床观察

目的：探讨吉西他滨＋DDP联合放疗治疗食管癌纵隔淋巴结转移的疗效及不良反应。方法：收集43例以呼吸困难就诊的食管癌纵隔淋巴结转移患者，采用GP方案化疗（吉西他滨1．0g／m^2，d1,8；顺铂30mg／m^2，d2-4。每21—28天1个周期）。化疗1—2周期后开始行放疗，6MV—X线照射，DT2Gy／次，5次／周，总剂量DT 50Gy-68Gy。结果：本组病例总有效率73．9％。结论：吉西他滨＋顺铂联合放疗治疗食管癌纵隔淋巴结转移有明显疗效。

Clinical observation of chemotherapy with regimen GP combined with radiotherapy in the treatment of esophageal carcinoma with mediastinal metastasis

Objective：To investigate the effects and side effects of gemcitabine plus cisplatine combined with radiotherapy in the treatment of esophageal carcinoma with mediastinal metastasis, nethods：Fourty three cases with esophageal carcinoma with mediastinal metastasis were enrolled in this study. They were treated with gemcitabine （ 1.0g/m^2, d1,8 ） and cisplatine （30mg/m^2, d2-4 ） with intervals of 21 to 28 days. After 1 to 2 cycles, the radiotherapy （6MV -X ray ,2Gy per fraction,5 days per week ,total dose 50Gy -68Gy） were followed. Results ：The response rate （RR） was 73.9% in all cases. Conclusion：The effects were significant of gemcitabine plus cisplatine combined with radiotherapy in the treatment of esophageal carcinoma with mediastinal metastasis.