| 白藜芦醇对老年性痴呆小鼠认知功能的影响 |
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| 引用本文： | 罗莉,黄忆明. 白藜芦醇对老年性痴呆小鼠认知功能的影响[J]. 中南大学学报(医学版), 2006, 31(4): 566-569 |
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| 作者姓名： | 罗莉 黄忆明 |
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| 作者单位： | 武汉市疾病预防控制中心;中南大学公共卫生学院营养与食品卫生学系,长沙,410078 |
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| 摘 要： | 目的：研究白藜芦醇（resveratrol，Res）对老年性痴呆小鼠认知功能的影响及作用机制，同时评价其对生殖系统的作用。方法：成年健康昆明种雌性小鼠84只，根据跳台实验成绩随机分为6组，每组14只，A组行假手术，B组为模型组[OVX＋D-galatose（D-gal）]，C组为灌胃雌激素对照组（OVX＋D-gal＋己烯雌酚），D为Res低剂量组（OVX＋D-gal＋低剂量Res），E为Res中剂量组（OVX＋D-gal＋中剂量Res），F为Res高剂量组（OVX＋D-gal＋高剂量Res）。结果：各剂量Res均可在一定程度上提高模型小鼠行为学测试成绩，抑制血清和脑组织SOD活力下降，减少MDA生成，同时抑制脑组织乙酰胆碱酯酶活力，减少海马bax表达；Res各剂量组小鼠子宫内膜均呈萎缩性改变。结论：Res对老年性痴呆小鼠认知功能具有一定保护作用，其作用机制可能为抗氧化、抑制乙酰胆碱酯酶活力和抗凋亡，Res无促进老年性痴呆小鼠子宫内膜增生作用。
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| 关 键 词： | 白藜芦醇 老年性痴呆 认知功能 生殖系统 小鼠 |
| 文章编号： | 1672-7347（2006）04-0566-04 |
| 收稿时间： | 2005-06-16 |
| 修稿时间： | 2005-06-16 |
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| LUO Li,HUANG Yi-ming.
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| Authors: | LUO Li HUANG Yi-ming |
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| Affiliation: | Deparment of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha 410078, China. |
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| Abstract: | OBJECTIVE: To explore the effect of resveratrol on the cognition of Alzheimer's mice (AD) and its mechanism, and to assess its action on the reproduction system. METHODS: According to the results of step-down test, 84 Kunming female mice were randomly divided into 6 groups: Group A [sham operated+1% CMC-Na (0.01 mL/g)], Group B [ovariectomy+D-galactose+1% CMC-Na (0.01 mL/g)], Group C [ovariectomy+D-galactose+0.05 mg/(kg.d) Diethylstilbestrol], Group D [ovariectomy+D-galactose+15 mg/(kg.d) Res], and Group E [ovariectomy+D-galactose injected+45 mg/(kg.d) Res], and Group F [ovariectomy+D-galactose +135 mg/(kg.d) Res]. Experimental cycle was 60 days. RESULTS: Resveratrol of every dosage could improve the performance records of behavior tests in AD mice,could inhibit the SOD vitality and the MDA level both in the serum and in the brain, and could suppress the acetylcholinesterase vitality and the bax expression. Resveratrol has no endometrial hyperplasia effect. CONCLUSION: Resveratrol can improve the cognitive ability of AD mice, which may contribute to the resveratrol's antioxidation and antiapoptosis, and can modulate acetylcholinesterase. Resveratrol has no side-effect of endometrial hyperplasia on AD mice. |
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