改良电休克治疗难治性精神分裂症的疗效分析

目的:探讨改良电休克治疗(MECT)对难治性精神分裂症的临床疗效、不良反应及安全性。方法:对56例难治性精神分裂症患者在服用原抗精神病药物治疗的基础上合并MECT治疗,并于治疗前后分别采用阳性与阴性症状量表(PANSS)、副反应量表(TESS)及韦氏记忆量表(WMS)评定疗效及不良反应。结果:合并MECT治疗后PANSS评分明显降低(P<0.01)。治疗后第1天WMS评分明显下降,1、2周后逐渐恢复。结论:MECT治疗对难治性精神分裂症有确切疗效,且不良反应少。

Efficacy of Modified Electroconvulsive Therapy in Treatment-refractory Schizophrenia

Objective:To explore the efficacy and side effects of modified electroconvulsive therapy(MECT) in treatment-refractory schizophrenia.Methods:56 patients with TRS who had received antipsychotic medication were assigned to receive MECT,and assessed with the positive and negative syndrome scale(PANSS) 、treatment emergent symptoms scale(TESS) and Wechsler memory scale(WMS) before and after treatment.Results:The PANSS scores decreased significantly after MECT(P<0.01) .The WMS scores decreased significantly at 1 day after the endpoint of MECT.but there were no significant difference between before and After1、2weeks of endpoint of MECT.Conclusions:MECT was effective in TRS,and it had little side effects.