Involvement of TSC genes and differential expression of other members of the mTOR signaling pathway in oral squamous cell carcinoma |
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| Authors: | Sanjukta Chakraborty SM Azeem Mohiyuddin KS Gopinath Arun Kumar |
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| Affiliation: | (1) Department of Molecular Reproduction Development and Genetics, Indian Institute of Science, Bangalore, India;(2) RL Jalappa Hospital and Research Centre, Kolar, India;(3) Bangalore Institute of Oncology, Bangalore, India |
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| Abstract: | Background Despite extensive research, the five-year survival rate of oral squamous cell carcinoma (OSCC) patients has not improved. Effective treatment of OSCC requires the identification of molecular targets and signaling pathways to design appropriate therapeutic strategies. Several genes from the mTOR signaling pathway are known to be dysregulated in a wide spectrum of cancers. However, not much is known about the involvement of this pathway in tumorigenesis of OSCC. We therefore investigated the role of the tumor suppressor genes, TSC1 and TSC2, and other members of this pathway in tumorigenesis of OSCC. |
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