Age-related spatial and nonspatial short-term memory in Cav2.1α1 mutant mice, Rolling Nagoya |
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Authors: | Eiki Takahashi Kimie Niimi Chitoshi Itakura |
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Affiliation: | aRIKEN Brain Science Institute, Research Resources Center, Hirosawa 2-1, Wako, Saitama 351-0198, Japan |
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Abstract: | Aged heterozygous Rolling Nagoya mice carrying Cav2.1α1 mutation show deficits with regard to spatial short-term memory using hippocampus-related object location test, but not with regard to nonspatial memory using perirhinal cortex-related object recognition test. In hippocampus, wild-type Cav2.1α1 mRNA exhibited lower expression and mutant-type expression was higher in aged heterozygous mice. In perirhinal cortex, there were no significantly different expressions. Alteration of age-dependent expressions of Cav2.1 channels differs in different regions with related effects on behavioral performances. |
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Keywords: | Rolling Nagoya mice Aging Spatial memory Object location test Object recognition test Real-time qRT-PCR Hippocampus Perirhinal cortex |
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