Initiation of apoptosis in hepatocytes during prolonged arterial hypotension and postresuscitation period |
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| Authors: | N V Nosova V L Kozhura I S Novoderzhkina |
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| Institution: | (1) Laboratory of Experimental Therapy of Terminal States, Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | An increase in activity of Ca2+, Mg2+-dependent endonucleases on the second hour of hypotension coincided with the presence of DNA fragments in agarose gel. A
correlation was established between the duration of hypotension, Ca2+, Mg2+-dependent endonuclease activity, and intensity of nuclear DNA fragmention. Apopotosis of hepatocytes is triggered during
ischemia and develops during reperfusion.
Translated fromByulleten' Eksperimental'noi Biologii i Meditisiny, Vol. 125, No. 3, pp. 285–288, March, 1998 |
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| Keywords: | apoptosis DNA fragmentation Ca 2+ Mg 2+-dependent endonucleases hepatocyte nuclei arterial hypotension |
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