| 膀胱移行细胞癌DBCCR1基因启动子甲基化分析 |
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| 引用本文： | 米军,段建敏,岳中瑾,张建平,李朝明.膀胱移行细胞癌DBCCR1基因启动子甲基化分析[J].兰州医学院学报,2006,32(1):1-3. |
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| 作者姓名： | 米军 段建敏 岳中瑾 张建平 李朝明 |
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| 作者单位： | 兰州大学第二医院,泌尿外科,甘肃,兰州,730030;兰州长风医院泌尿外科,甘肃,兰州,730060;陇南市第一医院泌尿外科,甘肃,陇南,746000 |
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| 摘 要： | 目的探讨膀胱移行细胞癌DBCCR1基因启动子甲基化状态及其临床意义。方法应用甲基化特异性PCR方法检测40例膀胱移行细胞癌和8例正常膀胱粘膜组织中DBCCRI基因甲基化程度，x^2检验分析其甲基化程度与膀胱癌病理分级分期之间的关系。结果正常膀胱组织未检测到DBCCR1基因启动子甲基化，在膀胱移行细胞癌启动子甲基化扩增阳性化率达42．5％，与膀胱癌病理分级分期没有相关性（P〉0．05）。结论DBCCR1基因启动子异常高甲基化是其失活的主要机制之一，也是膀胱移行细胞癌中一早期事件。
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| 关 键 词： | 膀胱移行细胞癌 DBCCR1基因 甲基化 |
| 文章编号： | 1000-2812（2006）01-0001-03 |
| 收稿时间： | 2005-12-20 |
| 修稿时间： | 2005年12月20 |
Analysis of promoter methylation of DBCCR1 gene in bladder transitional cell carcinoma |
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| MI Jun, DUAN Jian-min, YUE Zhong-jin, ZHANG Jian-ping, LI Zhao-ming.Analysis of promoter methylation of DBCCR1 gene in bladder transitional cell carcinoma[J].Journal of Lanzhou Medical College,2006,32(1):1-3. |
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| Authors: | MI Jun DUAN Jian-min YUE Zhong-jin ZHANG Jian-ping LI Zhao-ming |
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| Institution: | 1. Department of Urology, The Second Hospital of Lanzhou University, Lanzhou, 730030, China; 2. Changfen Hospital of Lanzhou City, Lanzhou, 730060, China; 3. The First Hospital of Longnan City, Longnan, 736000, Gansu, China |
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| Abstract: | Objective To evaluate promoter methylation of DBCCRl and its clinical significance. Methods DBCCRl methylation was examined in 40 cases of BTCC and 8 cases of normal urothelium by methylation specific PCR, x2 test was used to assess the relationship between the degree of methylation and tumor stage. Results DBCCRl methylation was found in 42.5%(17 of 40) cancer tissues and in 0%(0 of 8) normal urothelium. There was no significant difference between tumor grade and stage(P > 0.05). Conclusion Aberrant promoter hypermethylation is one of the mechanisms for inactivation of DBCCRl gene and an early event in bladder transitional cell carcinoma. |
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| Keywords: | bladder transitional cell carcinoma DBCCR1 gene methylation |
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