Traumatic brain injury is a rarely reported cause of growth hormone deficiency |
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Authors: | McDonald Anna Lindell Margaretha Dunger David B Acerini Carlo L |
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Institution: | a Department of Pediatrics, University of Cambridge, Cambridge, UK b KIGS, Pfizer Inc, Stockholm, Sweden. |
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Abstract: | We determined the frequency of traumatic brain injury (TBI)-related growth hormone deficiency (GHD) from a large registry of growth hormone-deficient subjects and compared these subjects' clinical characteristics with those of children with idiopathic growth hormone deficiency (IGHD). A surprisingly small number of subjects with TBI-induced GHD (n = 141) were registered compared with those with IGHD (n = 23,722). At onset of treatment, the subjects with TBI-induced GHD were older (P = .045), had lower height velocity (P < .001), had a greater number of other pituitary hormone deficiencies (P < .001) and, after a year of recombinant human GH treatment, demonstrated a greater change in height velocity (P = .016). We speculate that TBI-induced GHD may be a neglected phenomenon in childhood, and recommend prospective longitudinal studies to explore its natural history and frequency. |
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Keywords: | BMI Body mass index GHD Growth hormone deficiency IGHD Idiopathic growth hormone deficiency ITT Insulin tolerance test rhGH recombinant human growth hormone SDS Standard deviation score TBI Traumatic brain injury |
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