Double Trouble: A Case Series on Concomitant Genetic Aberrations in NSCLC |
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| Authors: | Nele Van Der Steen Yves Mentens Marc Ramael Leticia G Leon Paul Germonpré Jose Ferri David R Gandara Elisa Giovannetti Godefridus J Peters Patrick Pauwels Christian Rolfo |
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| Institution: | 1. Center for Oncological Research, University of Antwerp, Antwerp, Belgium;2. Department of Pathology, Antwerp University Hospital, Antwerp, Belgium;3. Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands;4. Department of Pneumology, AZ Herentals, Herentals, Belgium;5. Department of Pathology, AZ Herentals, Herentals, Belgium;6. Laboratory of Cell Biology and Histology, University of Antwerp, Antwerp, Belgium;7. Cancer Pharmacology Lab, AIRC Start-Up Unit, University of Pisa, Pisa, Italy;8. Department of Pneumology, AZ Maria Middelares, Ghent, Belgium;9. Phase I - Early Clinical Trials Unit, Oncology Department, Antwerp University Hospital, Antwerp, Belgium;10. Department of Medicine, University of California Davis Cancer Center, Sacramento, CA |
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| Abstract: | Several oncogenic drivers have been identified in non–small cell lung cancer. Targeted therapies for these aberrations have already been successfully developed and implemented in clinical practice. Owing to improved sensitivity in genetic testing, more and more tumors with multiple driver mutations are identified, resulting in dilemmas for treating physicians whether and which targeted therapy to use. In this case series, we provide an overview of patients with intrinsic double mutations in oncogenic drivers and their reported response to targeted therapies, with a focus on epidermal growth factor receptor, anaplastic lymphoma kinase, cMET, and Kirsten rat sarcoma viral oncogene. We also include an unpublished case report on a patient with an epidermal growth factor receptor L858R and cMET exon 14 skipping. |
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| Keywords: | ALK cMET EGFR KRAS Non–small cell lung cancer |
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