| 水合氯醛糖浆生产工艺的研究 |
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| 引用本文： | 赵蕾,;唐辉,;袁天荣,;董琼,;赵雪梅.水合氯醛糖浆生产工艺的研究[J].现代中药研究与实践,2014(4):38-40. |
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| 作者姓名： | 赵蕾 ;唐辉 ;袁天荣 ;董琼 ;赵雪梅 |
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| 作者单位： | [1]山东大学附属省立医院,山东济南250021; [2]山东中医药大学,山东济南250355 |
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| 摘 要： | 目的研究水合氯醛糖浆的生产工艺。方法通过优选蔗糖、防腐剂等的用量来保证本品的口味和稳定性,制定了严格的单糖浆、5%羟苯乙酯溶液、羧甲基纤维素钠的配制方法。结果糖浆剂的口感较好,在口腔黏膜和胃肠道中粘度增加,延长了其在口腔和胃肠道中的滞留时间,生物利用度高于水合氯醛溶液,适用于儿科临床的检查和治疗。结论实验证明生产工艺可行。
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| 关 键 词： | 水合氯醛 糖浆剂 生产工艺 |
Research on Production of Chloral Hydrate Syrup |
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| Institution: | ZHAO Lei ,TANG Hui ,YUAN Tian-rong,DONG Qiong, ZHAO Xue-mei (1. Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021 ,China;2.Shandong University of Traditional Chinese Medicine, Jinan 250355,China) |
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| Abstract: | Objective To research the technology on production of chloral hydrate syrup. Methods To ensurethe taste and stability of the product by optimizing the amount of sucrose and preservative and developing thepreparation method of simple syrup, 5% Ethylparaben solution, and Sodium Carboxymethyl cellulose as well.Results Syrup has a better taste. The viscosity in the oral mucosa and gastrointestinal tract increased, therefore,the retention time in oral cavity and gastrointestinal tract prolonged. The bioavailability of Chloral hydrate syrup ishigher than that of the solution form, which is better for pediatric clinical examination and treatment. ConclusionExperiments show that the production process is feasible. |
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| Keywords: | chloral hydrate syrups production technology |
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