中国3766例非综合征性总唇裂的分析

为了解我国１９８８￣１９９２年非综合征性总唇裂的流行病学特征及发生率的动态变化趋势，采用以医院为单位的整群抽样方法，对全国５００所医院孕２８周至产后７天的３２４６４０８例围产儿，３７６６例非综合征性总唇裂病例进行性分析。结果：我国非综合征性总唇裂发生率为１１．６／万，其中单纯性唇裂为３．８／万，唇裂合并腭裂为７．８／万，５年发生率无显著性差异（Ｐ〉０．１）。城乡非综合征性总唇裂的发生率（１１．７／

Nonsyndromic cleft lip with or without cleft palate in Chinese population: analysis of 3766 cases]

A retrospective study was conducted to evaluate the variation trend in the incidence and epidemiological characteristics of nonsyndromic cleft lip with or without cleft palate in Chinese population. From 1988 to 1992, data were collected from more than 500 hospital-based units involved in a monitoring program and were analyzed by the National Center for Birth Defects Monitoring. The monitored subjects were the hospitalized births from 28 weeks gestation to a period within 7 days after delivery, which included 3246 408 perinatals and 3766 cases. The total incidence of nonsyndromic cleft lip with or without cleft palate was 11.6/10,000; the total incidence of celft lip alone was 3.8/10,000 and that of cleft lip with cleft palate was 7.8/10,000; no significant variation was noted in the annual incidence from 1988 to 1992. The incidence in males was 13.3/10,000, and 9.5/10,000 in females; there was a significant difference (P < 0.01). Of all the 3766 cases, cleft lip with cleft palate accounted for 67%, unilateral cleft lip 28% and unilateral cleft lip with cleft palate 43%. Left cleft lip and left cleft lip with cleft palate constituted 21% and 29% respectively. The sex-ratio was 1.6:1 for nonsyndromic cleft lip with or without cleft palate. It could be concluded that the incidence of nonsyndromic cleft lip with or without cleft palate showed no variation trend in China. Although no difference was found between urban and rural areas, the susceptibility to the defect was higher in males than in females. Cleft lip with cleft palate was more common than other types. There was a predominance of unilateral defects, of which most were on the left side.