Synthesis and antibacterial activity of 4-benzoyl-1-(4-carboxy-phenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid and derivatives |
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Authors: | İshak Bildirici Ahmet Şener Ekrem Atalan Abdulhamit Battal Hasan Genç |
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Affiliation: | (1) Organic Chemistry Division, Chemistry Department, Faculty of Arts and Sciences, Yüzüncü Yıl University, 65080 Van, Turkey;(2) Molecular Biology Division, Biology Department, Faculty of Arts and Sciences, Yüzüncü Yıl University, 65080 Van, Turkey |
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Abstract: | A new 1H-pyrazole-3-carboxylic acid 2, along with hydrazono-pyridazinone 3, a by-product, and its derivatives 4–7 were synthesized and the structures confirmed by infrared (IR) and 1H and 13C nuclear magnetic resonance (NMR) data. These new compounds were evaluated for their antibacterial activities against Gram-positive and Gram-negative bacteria using the tube dilution method. The minimal inhibitory concentrations (MICs) experiments revealed that most compounds exerted inhibitor effects against Klebsiella pneumonia, Escherichia coli, Bacillus subtilus, and Xanthomonas compestris test microorganisms. Moreover, the results showed that the pyrazolo[3,4-d]pyridazine compounds were the best compounds of the series, exhibiting antibacterial activity against both Gram-positive and Gram-negative bacteria. |
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Keywords: | Pyrazole Hydrazono-pyridazine Pyrazolo[3,4-d]pyridazine Antibacterial activity |
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