| 高效液相色谱法测定狗皮巴布膏中肉桂的体外透皮吸收 |
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| 引用本文： | 郝美荣,李长龄. 高效液相色谱法测定狗皮巴布膏中肉桂的体外透皮吸收[J]. 中草药, 1998, 29(1): 23-25 |
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| 作者姓名： | 郝美荣 李长龄 |
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| 作者单位： | 北京医科大学药学院生化药理室!100083 |
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| 摘 要： | 应用高效液相色谱法（HPLC）观察了狗皮巴布膏体外经皮渗透性，采用两室扩散模型对脱毛小鼠皮进行了实验观察。结果表明狗皮膏巴布剂透皮吸收的可行性，其透皮量随着药物浓度的增加和时间的延长而增多，低浓度12．5mg生药／mL在180min时的累积透皮量已不再增加。此结果为狗皮膏巴布剂的临床应用提供了实验基础。
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| 关 键 词： | 透皮吸收 HPLC 肉桂酸 |
| 收稿时间： | 1996-04-19 |
Studies on Transdermal Absorption of Goupibabu Plaster in vitro Using HPLC |
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| Hao Meirong and Li Changling. Studies on Transdermal Absorption of Goupibabu Plaster in vitro Using HPLC[J]. Chinese Traditional and Herbal Drugs, 1998, 29(1): 23-25 |
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| Authors: | Hao Meirong and Li Changling |
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| Affiliation: | Department of Biochemistry, College of Pharmacy, Beijing Medical University, Beijing 100083;Department of Biochemistry, College of Pharmacy, Beijing Medical University, Beijing 100083 |
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| Abstract: | Percutaneous absorption of Goupibabu Plaster was studied using HPLC,adopting simple diffusion cell model to observe its permeation through hairless mouse skin. The result showed that Goupibabu plaster can evidently permeate through the skin,and the amount absorbed increased exponentially with content and time. |
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| Keywords: | Transdermal Absorption HPLC Goupibabu Plaster |
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