| 齐拉西酮与奥氮平治疗以阴性症状为主的精神分裂症对照研究 |
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| 引用本文： | 邹晓华,周云芳,何莲英,金艳,戎伟.齐拉西酮与奥氮平治疗以阴性症状为主的精神分裂症对照研究[J].海峡药学,2008,20(3):87-89. |
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| 作者姓名： | 邹晓华 周云芳 何莲英 金艳 戎伟 |
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| 作者单位： | 1. 浙江丽水市第二人民医院,丽水,323000
2. 浙江诸暨市第三人民医院,诸暨,311800 |
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| 摘 要： | 探讨齐拉西酮对以阴性症状为主的精神分裂症的疗效与不良反应。方法将83例以阴性症状为主的精神分裂症患者,随机分成齐拉西酮组(n=42)和奥氮平组(n=41)进行为期8周的治疗,采用阳性与阴性症状量表(PANSS)、阴性症状评定量表(SANS)评定疗效,不良反应量表(TESS)评定不良反应。结果齐拉西酮与奥氮平疗效相当,对认知功能的改善无显著性差异(P>0.05),不良反应发生率有显著性差异(P<0.05)。结论齐拉西酮治疗以阴性症状为主的精神分裂症疗效确切,不良反应少。
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| 关 键 词： | 齐拉西酮 奥氮平 阴性症状 精神分裂症 |
| 文章编号： | 1006-3765(2008)-03-0087-03 |
A comparative study of ziprasidone and olanzapine in schizophrenia with predominantly negative symptoms |
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| ZOU Xiao-hua,ZHOU Yun-fang,HE Lian-ying,JIN Yan,RONG Wei.A comparative study of ziprasidone and olanzapine in schizophrenia with predominantly negative symptoms[J].Strait Pharmaceutical Journal,2008,20(3):87-89. |
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| Authors: | ZOU Xiao-hua ZHOU Yun-fang HE Lian-ying JIN Yan RONG Wei |
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| Institution: | ZOU Xiao-hua1,ZHOU Yun-fang1,HE Lian-ying2,JIN Yan1,RONG Wei1 |
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| Abstract: | OBJECTIVE To compare the efficacy and side effects of ziprasidone and olanzapine in the treatment of schizophrenia with predominantly negative symptoms.METHODS 83 Schzophrenia inpatients with predominantly negative symptoms were randomly assigned to ziprasidone group(42)and olanzapine group(41),The efficacy and side effects were evaluated with PANSS,SANS and TESS.RESULTS There was no significant difference in efficacy between the two groups(P>0.05),ziprasidone had fewer side effects than olanzapine(P<0.05).CONCLUSION Ziprasidone is an effective and safe medicine in the treatment of schizophrenia with predomintly negative symptoms. |
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| Keywords: | Ziprasidone Olanzapine Negative symptom Schizophrenia |
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