| 参麦注射液对大鼠肾缺血再灌注损伤中SOD、MDA作用的研究 |
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| 引用本文： | 林明佳 何小洪 谢利英 莫蝶仪 何振丹 关健明 董晓先. 参麦注射液对大鼠肾缺血再灌注损伤中SOD、MDA作用的研究[J]. 河南职工医学院学报, 2005, 17(5): 266-267 |
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| 作者姓名： | 林明佳 何小洪 谢利英 莫蝶仪 何振丹 关健明 董晓先 |
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| 作者单位： | [1]广州医学院临床一系2003级6班 [2]广州医学院病理生理学教研室,广东广州510182 |
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| 摘 要： | 目的 探讨参麦注射液在大鼠肾缺血-再灌注损伤中的抗氧化作用。方法 通过建立大鼠急性肾再灌注损伤模型，测定参麦注射液对肾缺血-再灌注后肾组织SOD活力与MDA含量的变化。结果 与对照组相比，使用参麦注射液后，在再灌注0h、1h、12h及24h后肾组织SOD活力明显升高（P值分别〈0．01，0．05，0．01），MDA含量明显降低（P值分别〈0．05，0．01，0．05）。结论 参麦注射液在大鼠肾缺血一再灌注损伤模型中，有抗自由基损伤和减轻脂质过氧化的作用。
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| 关 键 词： | 参麦注射液 大鼠 肾 缺血-再灌注损伤 |
| 文章编号： | 1008-9276(2005)05-0266-02 |
| 收稿时间： | 2005-03-02 |
| 修稿时间： | 2005-03-02 |
Resisting the Oxidation of Shen mai Injection on Renal Ischemia/Reperfusion Injuries in Rats |
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| LIN Ming, HE Xiao-hong, XIE Li-ying , MO Die-yi , HE Zheng-dan , GUAN Jiang-ming , DONG Xiao-xian. Resisting the Oxidation of Shen mai Injection on Renal Ischemia/Reperfusion Injuries in Rats[J]. Journal of Henan Medical College For Staff and Workers, 2005, 17(5): 266-267 |
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| Authors: | LIN Ming HE Xiao-hong XIE Li-ying MO Die-yi HE Zheng-dan GUAN Jiang-ming DONG Xiao-xian |
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| Affiliation: | 1. The First Faculty of Clinical Medicine, Guangzhou Medical College ; 2. Department of Pathophysiology , Guangzhou Medical College, Guangzhou Guangdong 510182, China |
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| Abstract: | Objective To study the anti-oxidant effects of shenmai injection on rats with renal ischemia reperfusion injuries.Methods Shenmai injection was administered intrapertioneally in rats for every 6 hours from 2 days before the ischemia until 0,1,12,24 hours after reperfusion.Results SOD,MDA were significantly higher(P<0.01 P<0.05 P<0.01 respectively),while the concentration of MDA was significantly lower(P<0.05 P<0.01 P<0.05 respectively).Conclusion Shenmai injection may have anti-oxidative properties against renal ischemia reperfusion injuries in rats,possibly by alleviating the damages caused by free radicals and lipid peroxidation. |
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| Keywords: | shenmai injection rat kidney renal ischemia reperfusion injury |
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