2型糖尿病家系一级亲非糖尿病同胞的血脂水平研究

目的 研究２型糖尿病（２型ＤＭ）家系一级亲非ＤＭ同胞的血脂变化。方法 收集江浙籍２型ＤＭ家系３２０个。在排除ＤＭ和糖耐量减退（ＩＧＴ）的前提下，选择先让者同胞为观察组（３４７例），先证者或其同胞的配偶为对照组（３２６例），并按年龄和ＢＭＩ分成亚型，进行血脂水平比较。结果 ２型ＤＭ家系一级亲非ＤＭ同胞ＴＧ、ＴＣ，ＬＤＬ水平升高，ＨＤＬ水平降低，年龄超过４０岁以后尤其明显。结论 ２型ＤＭ家系一级亲在糖

A study of blood lipid levels in non-diabetic first-degree siblings of type 2 diabetes families

Objective To study the changes of blood lipid levels in non-diabetic first-degree siblings of type 2 diabetes families.Methods 320 type 2 diabetes families were recruited from Shanghai.The observation group comprised 347 first-degree siblings with normal glucose tolerance (NGT).The control group comprised 326 NGT spouses of probands and siblings.The study groups were divided into subgroups according to age and BMI.Blood lipid levels were compared between the observe and control groups.Results The TC,TG,LDL levels in non-diabetic first-degree siblings of type 2 diabetes families were higher and the HDL level in this population was lower than control,especially in those aged over 40yr.Conclusion Lipid abnormalities may be present in NGT relatives of type 2 diabetes families.Blood lipid monitoring is important for the early prevention and treatment of DM.