Comparison of intermittent injection of nondepolarizing solution with a single flush of UW solution for donor heart preservation |
| |
Authors: | Hisashi Miyamoto Makoto Sunamori Akio Suzuki |
| |
Institution: | (1) Department of Thoracic-Cardiovascular Surgery, Tokyo Medical and Dental University, School of Medicine, 1-5-45, Yushima, 113 Bunkyo-ku, Tokyo, Japan |
| |
Abstract: | Isolated canine hearts were preserved for 6 h at 5°C followed by normothermic reperfusion for 2 h. The dogs were divided into two groups of nine hearts each; group 1 received a nondepolarizing preservation solution in multidose, and group 2 received a single flush of University of Wisconsin (UW) solution. Serum MB-CK and mitochondrial aspartate aminotransferase (m-AAT) concentrations and calcium overload during reperfusion were lower in group 1 than in group 2. At the end of reperfusion, myocardial ATP and total adenine nucleotide concentrations were higher and mitochondrial morphology appeared more intact in group 1 than in group 2. Left ventricular diatolic function was preserved better in group 1 than in group 2. These results suggest that in 6-h heart preservation, a nondepolarizing solution applied in multidose fashion protects the myocardium from the deleterious effects of hypothermia and cardioplegia better than a single flush of UW solution. |
| |
Keywords: | Heart preservation canine UW solution heart preservation Nondepolarizing solution heart preservation Preservation heart canine |
本文献已被 SpringerLink 等数据库收录! |
|