尼麦角林防治脑梗死后认知功能障碍的临床研究

目的脑梗死后认知功能障碍发生率高达20％～30％．临床亟待防治有效的药物。了解尼麦角林防治脑梗死后认知功能障碍发生的效果以及探讨其作用机理。方法脑梗死患者随机分成治疗组和对照组，治疗组服用尼麦角林。入院1周内和3个月后进行MMSE评分和经颅多谱勒检查。结果3个月后对照组MMSE评分在记忆力、计算能力和回忆能力方面显著下降，大脑血流速度明显下降；而治疗组的评分下降则不明显。大脑血流速度明显提高。结论尼麦角林在防治血管性认知功能障碍方面有显著的效果。改善脑的血供可能是尼麦角林改善脑梗死认知功能障碍的原因之一。

Clinical trial:effect of nicergoline on prevention and treatment of cognition disturbance in patients with cerebral infarction

Objective The incidence of cognition disturbance after cerebral infarction is about 20%-30% and effective drug for prevention and treatment of it is expected.To investigate the effect of nicergoline on prevention from cognition disturbance after cerebral infarction and to explore its mechanism.Methods The patients with cerebral infarction were divided randomly into two groups: treatment with nicergoline and control.To measure MMSE score and cerebral blood flow with TCD within one week and after three months respectively.Results The MMSE score and blood flow in control group decreased obviously in memory,calculation and recognition and those in treatment group did not change much.Conclusion Nicergoline has good effect in prevention from vascular cognition disturbance and improvement of blood supply may be one of the mechanisms.